Sandbox Reserved 1726: Difference between revisions

[[Image:glycinehelicesorange.png|300 px|right|thumb|Figure 2. Rare Glycine helices on Anaplastic Lymphoma Kinase; The structure of extracellular ALK is shown in a perpendicular, cross sectional way, highlighted in orange. In black, hydrogen bonds are structured in a hexagonal-like way. Made using [https://www.rcsb.org/structure/7N00 7N00]]]Located between the THB-like domain and the TNF-like domain, the <scene name='90/904331/Polyg_region1/4'>Poly-Glycine Region</scene> has an important structural role.<ref name="Reshetnyak" /> The GlyR domain also has a rare and unique structure of left-handed glycine helices with hexagonal hydrogen bonding (Figure 2).<ref name="Reshetnyak" /> These 14 glycine helices are unique to ALK's function among other tyrosine kinases.<ref name="Reshetnyak" /> These helices are rigid structures, providing a strong anchor for the ligand binding site while the other domains undergo conformational rearrangements.<ref name="Reshetnyak" />