Sandbox Reserved 1703: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
=Metabotropic Glutamate Receptor 2= | α=Metabotropic Glutamate Receptor 2= | ||
<StructureSection load='' size='350' frame='true' side='right' caption='Fully Active mGlu2 with G-Protein Bound (PDB: [[7mts]])' scene='90/904307/Main_active_image/2'> | <StructureSection load='' size='350' frame='true' side='right' caption='Fully Active mGlu2 with G-Protein Bound (PDB: [[7mts]])' scene='90/904307/Main_active_image/2'> | ||
| Line 33: | Line 33: | ||
====G-Protein Recognition==== | ====G-Protein Recognition==== | ||
In order for the G-protein to bind to mGlu2, so that it can be fully active, the G-protein has to be recognized by the receptor. Transition to the active state also reorients helix 3 in both monomers to enable binding to the G-protein; Yet only one chain is required for full receptor activation. The intracellular region of helix 3 contributes the main interactions with the α-subunit of the G-protein. Intracellular Loop 2(ICL2) also builds a polar interaction network with the G-protein through its ionic interactions with the <scene name='90/904308/ | In order for the G-protein to bind to mGlu2, so that it can be fully active, the G-protein has to be recognized by the receptor. Transition to the active state also reorients helix 3 in both monomers to enable binding to the G-protein; Yet only one chain is required for full receptor activation. The intracellular region of helix 3 contributes the main interactions with the α-subunit of the G-protein. Intracellular Loop 2(ICL2) also builds a polar interaction network with the G-protein through its ionic interactions with the <scene name='90/904308/Active_structure/6'>α-subunit</scene> of the G-protein. The ionic interactions formed further destabilize the inactive conformation so that the G-protein can be recognized and mGlu2 becomes fully active<ref name="Lin"/>. | ||
====G-protein Binding==== | ====G-protein Binding==== | ||