Sandbox Reserved 1703: Difference between revisions

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OCA, Jaime Prilusky, Ashley R. Wilkinson, R. Jeremy Johnson

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 [[Image:Domains of mGlu2.jpg|200 px|right|thumb|'''Figure 2.'''Show the regions of mGlu2.]]
-mGlu2 is a [https://en.wikipedia.org/wiki/Protein_dimer homodimer]. Dimerization of mGlu2 is required to relay glutamate binding from the ECD to its transmembrane domain TMD. The homodimer of mGlu2 contains an alpha chain and a beta chain. Occupation of both ECDs with the agonist, glutamate, is necessary for a fully active mGlu2<ref name="Du">Du, Juan, et al. “Structures of Human mglu2 and mglu7 Homo- and Heterodimers.” Nature News, Nature Publishing Group, 16 June 2021, https://www.nature.com/articles/s41586-021-03641-w.></ref>. However, only one chain in the dimer is responsible for activation of the G-protein, this suggests an asymmetrical signal transduction mechanism for mGlu2<ref name="Lin"/>.
+mGlu2 is a [https://en.wikipedia.org/wiki/Protein_dimer homodimer]. Dimerization of mGlu2 is required to relay glutamate binding from the ECD to its TMD. The homodimer of mGlu2 contains an alpha chain and a beta chain. Occupation of both ECDs with the agonist, glutamate, is necessary for a fully active mGlu2<ref name="Du">Du, Juan, et al. “Structures of Human mglu2 and mglu7 Homo- and Heterodimers.” Nature News, Nature Publishing Group, 16 June 2021, https://www.nature.com/articles/s41586-021-03641-w.></ref>. However, only one chain in the dimer is responsible for activation of the G-protein, this suggests an asymmetrical signal transduction mechanism for mGlu2<ref name="Lin"/>.
 ===Inactive State===