Sandbox Reserved 1712: Difference between revisions
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=Anaplastic Lymphoma Kinase receptor= | =Anaplastic Lymphoma Kinase receptor= | ||
<StructureSection load='7n00' size='350' frame='true'side='right' caption='Anaplastic Lymphoma Kinase receptor PDB code: [https://www.rcsb.org/structure/7N00 7n00]' scene='90/904317/Dimer_full_colored/8'> | <StructureSection load='7n00' size='350' frame='true'side='right' caption='Anaplastic Lymphoma Kinase receptor PDB code: [https://www.rcsb.org/structure/7N00 7n00]' scene='90/904317/Dimer_full_colored/8'> | ||
[[Image:Image for proteo.jpg| | [[Image:Image for proteo.jpg|350 px|right|thumb|Figure 1:]] | ||
==Background== | ==Background== | ||
The anaplastic lymphoma kinase (ALK) was first discovered in 1994 as a tyrosine [https://en.wikipedia.org/wiki/Kinase kinase] in [https://en.wikipedia.org/wiki/Anaplastic_large-cell_lymphoma anaplastic large-cell lymphoma] (ALCL) cells.<ref>DOI: 10.3390/ijms19113448</ref> The specific type of tyrosine kinase ALK is classified as is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) and like other RTKs, it's an integral protein with extracellular and intracellular domains and is involved in transmembrane signaling and communication within the cell. ALK is commonly expressed in the development of the nervous system. Anaplastic lymphoma kinase receptor (ALKr) is the extracellular portion of the RTK that includes a binding surface for a ligand to bind. When the ALK activating ligand (ALKAL) binds to ALKr, this causes a conformational change of ALK, allowing two ALK-ALKAL complexes to interact with each other, which will then allow intracellular kinase domain of ALK to phosphorylate a tyrosine residue on a downstream enzyme, which will activate this enzyme and activate a signaling cascade. Abnormal forms of ALK are closely related to the formation of several cancers. <ref>DOI: 10.3390/ijms19113448</ref> | The anaplastic lymphoma kinase (ALK) was first discovered in 1994 as a tyrosine [https://en.wikipedia.org/wiki/Kinase kinase] in [https://en.wikipedia.org/wiki/Anaplastic_large-cell_lymphoma anaplastic large-cell lymphoma] (ALCL) cells.<ref>DOI: 10.3390/ijms19113448</ref> The specific type of tyrosine kinase ALK is classified as is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) and like other RTKs, it's an integral protein with extracellular and intracellular domains and is involved in transmembrane signaling and communication within the cell. ALK is commonly expressed in the development of the nervous system. Anaplastic lymphoma kinase receptor (ALKr) is the extracellular portion of the RTK that includes a binding surface for a ligand to bind. When the ALK activating ligand (ALKAL) binds to ALKr, this causes a conformational change of ALK, allowing two ALK-ALKAL complexes to interact with each other, which will then allow intracellular kinase domain of ALK to phosphorylate a tyrosine residue on a downstream enzyme, which will activate this enzyme and activate a signaling cascade. Abnormal forms of ALK are closely related to the formation of several cancers. <ref>DOI: 10.3390/ijms19113448</ref> | ||