Folylpolyglutamate synthase: Difference between revisions
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==Structure== | ==Structure== | ||
<StructureSection load='' size='400' side='right' caption='Folylpolyglutamate synthase complex with AMPPCP and Co+2 ion (pink) (PDB code [[2vor]])' scene='74/748269/Cv/1'> | <StructureSection load='' size='400' side='right' caption='Folylpolyglutamate synthase complex with AMPPCP and Co+2 ion (pink) (PDB code [[2vor]])' scene='74/748269/Cv/1'> | ||
FPGS binds to ATP, glutamate and folate (THF-(glu)n). Once <scene name='74/748269/Folate/1'>folate is bound</scene>, the enzyme undergoes a <scene name='74/748269/Folate_binding/2'>conformational change</scene> into the active form. In the <scene name='74/748269/Glu/1'>Yersinia pestis structure</scene> 3qcz, glutamate and ATP are bound but the folate binding site is empty. | FPGS binds to ATP, glutamate and folate (THF-(glu)n). Once <scene name='74/748269/Folate/1'>folate is bound</scene>, the enzyme undergoes a <scene name='74/748269/Folate_binding/2'>conformational change</scene> into the active form. In the <scene name='74/748269/Glu/1'>Yersinia pestis structure</scene> 3qcz, glutamate and ATP are bound but the folate binding site is empty. | ||