2vdb: Difference between revisions
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<StructureSection load='2vdb' size='340' side='right'caption='[[2vdb]], [[Resolution|resolution]] 2.52Å' scene=''> | <StructureSection load='2vdb' size='340' side='right'caption='[[2vdb]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vdb]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2vdb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_magnus"_prevot_1933 "diplococcus magnus" prevot 1933] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=NPS:(2S)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC+ACID'>NPS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=NPS:(2S)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC+ACID'>NPS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bm0|1bm0]], [[1e7a|1e7a]], [[1e7e|1e7e]], [[1e7g|1e7g]], [[1gni|1gni]], [[1h9z|1h9z]], [[1ha2|1ha2]], [[1hk1|1hk1]], [[1hk4|1hk4]], [[1hk5|1hk5]], [[1tf0|1tf0]], [[1uor|1uor]], [[1ysx|1ysx]], [[2bx8|2bx8]], [[2bxa|2bxa]], [[2bxb|2bxb]], [[2bxc|2bxc]], [[2bxd|2bxd]], [[2bxi|2bxi]], [[2bxo|2bxo]], [[2bxq|2bxq]], [[1ao6|1ao6]], [[1bj5|1bj5]], [[1bke|1bke]], [[1e78|1e78]], [[1e7b|1e7b]], [[1e7c|1e7c]], [[1e7f|1e7f]], [[1e7h|1e7h]], [[1e7i|1e7i]], [[1gnj|1gnj]], [[1hk2|1hk2]], [[1hk3|1hk3]], [[1n5u|1n5u]], [[1o9x|1o9x]], [[2bxe|2bxe]], [[2bxf|2bxf]], [[2bxg|2bxg]], [[2bxh|2bxh]], [[2bxk|2bxk]], [[2bxl|2bxl]], [[2bxm|2bxm]], [[2bxn|2bxn]], [[2bxp|2bxp]], [[2esg|2esg]], [[1gab|1gab]], [[1prb|1prb]], [[2j5y|2j5y]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bm0|1bm0]], [[1e7a|1e7a]], [[1e7e|1e7e]], [[1e7g|1e7g]], [[1gni|1gni]], [[1h9z|1h9z]], [[1ha2|1ha2]], [[1hk1|1hk1]], [[1hk4|1hk4]], [[1hk5|1hk5]], [[1tf0|1tf0]], [[1uor|1uor]], [[1ysx|1ysx]], [[2bx8|2bx8]], [[2bxa|2bxa]], [[2bxb|2bxb]], [[2bxc|2bxc]], [[2bxd|2bxd]], [[2bxi|2bxi]], [[2bxo|2bxo]], [[2bxq|2bxq]], [[1ao6|1ao6]], [[1bj5|1bj5]], [[1bke|1bke]], [[1e78|1e78]], [[1e7b|1e7b]], [[1e7c|1e7c]], [[1e7f|1e7f]], [[1e7h|1e7h]], [[1e7i|1e7i]], [[1gnj|1gnj]], [[1hk2|1hk2]], [[1hk3|1hk3]], [[1n5u|1n5u]], [[1o9x|1o9x]], [[2bxe|2bxe]], [[2bxf|2bxf]], [[2bxg|2bxg]], [[2bxh|2bxh]], [[2bxk|2bxk]], [[2bxl|2bxl]], [[2bxm|2bxm]], [[2bxn|2bxn]], [[2bxp|2bxp]], [[2esg|2esg]], [[1gab|1gab]], [[1prb|1prb]], [[2j5y|2j5y]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdb OCA], [https://pdbe.org/2vdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vdb RCSB], [https://www.ebi.ac.uk/pdbsum/2vdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vdb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[[ | [[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |