6ht7: Difference between revisions
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==Crystal structure of the WT human mitochondrial chaperonin (ADP:BeF3)14 complex== | ==Crystal structure of the WT human mitochondrial chaperonin (ADP:BeF3)14 complex== | ||
<StructureSection load='6ht7' size='340' side='right'caption='[[6ht7]]' scene=''> | <StructureSection load='6ht7' size='340' side='right'caption='[[6ht7]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT7 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6ht7]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HT7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPD1, HSP60 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HSPE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chaperonin_ATPase Chaperonin ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.9 3.6.4.9] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ht7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht7 OCA], [https://pdbe.org/6ht7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ht7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ht7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/CH60_HUMAN CH60_HUMAN]] Autosomal dominant spastic paraplegia type 13;Pelizaeus-Merzbacher-like disease due to HSPD1 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/CH60_HUMAN CH60_HUMAN]] Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. [[https://www.uniprot.org/uniprot/CH10_HUMAN CH10_HUMAN]] Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | |||
==See Also== | |||
*[[Chaperonin 3D structures|Chaperonin 3D structures]] | |||
*[[Heat Shock Protein structures|Heat Shock Protein structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Chaperonin ATPase]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Azem A]] | [[Category: Azem, A]] | ||
[[Category: Hirsch J]] | [[Category: Hirsch, J]] | ||
[[Category: Jebara F]] | [[Category: Jebara, F]] | ||
[[Category: Patra M]] | [[Category: Patra, M]] | ||
[[Category: Chaperone]] | |||
[[Category: Protein folding chaperonin]] | |||