Akt/PKB signaling pathway: Difference between revisions
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*[[PI3K Activation, Inhibition, & Medical Implications]] | *[[PI3K Activation, Inhibition, & Medical Implications]] | ||
PI3K can also be activated by [[G protein-coupled receptors]] (GPCRs), via G-protein βγ dimers or Ras which bind PI3K directly. In addition, the Gα subunit activates Src-dependent integrin signaling which can activate PI3K. | |||
==Phosphoinositide formation== | ==Phosphoinositide formation== | ||
The triphosphate form (PI(3,4,5)P3) binds Akt and [[phosphoinositide-dependent kinase 1]] (PDK1) so they accumulate in close proximity at the membrane. | The triphosphate form (PI(3,4,5)P3) binds Akt and [[phosphoinositide-dependent kinase 1]] (PDK1) so they accumulate in close proximity at the membrane. | ||