Sandbox Reserved 1713: Difference between revisions
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== Structure & Function == | == Structure & Function == | ||
The active state of the kinase is when two monomers have completed a conformational change and moved across the membrane to form a <scene name='90/904317/Dimer_full_colored/3'>dimer</scene>. | |||
===Domains=== | ===Domains=== | ||
[[Image:2d_image.jpg|400 px|center|thumb|Fig.1 Anaplastic Lymphoma Kinase and its domains. The region from NTR to the MAM is the Heparin Binding Domain. The TNFL-PXL are the extracellular domains and the EGF is the domain that binds the extracellular region with the extracellular region of the transmembrane. The TMH is the transmembrane domain. The kinase domain is the intracellular portion of the ALK.]] | [[Image:2d_image.jpg|400 px|center|thumb|Fig.1 Anaplastic Lymphoma Kinase and its domains. The region from NTR to the MAM is the Heparin Binding Domain. The TNFL-PXL are the extracellular domains and the EGF is the domain that binds the extracellular region with the extracellular region of the transmembrane. The TMH is the transmembrane domain. The kinase domain is the intracellular portion of the ALK.]] | ||
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<scene name='90/904318/Arg753/2'>Arg753</scene> | <scene name='90/904318/Arg753/2'>Arg753</scene> | ||
<scene name='90/904318/Gly747/1'>Gly747</scene> | <scene name='90/904318/Gly747/1'>Gly747</scene> | ||
<ref>DOI: 10.1038/s41586-021-03959-5</ref> | <ref>DOI: 10.1038/s41586-021-03959-5</ref> | ||
<ref>DOI: 10.1038/s41586-021-04141-7</ref> | <ref>DOI: 10.1038/s41586-021-04141-7</ref> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||