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 ==Introduction==
-Metabotropic glutamate receptors are found in the central nervous system and play a critical role in modulating cell excitability and synaptic transmission<ref name="Lin">Lin, Shuling, et al. “Structures of GI-Bound Metabotropic Glutamate Receptors mglu2 and mglu4.” Nature News, Nature Publishing Group, 16 June 2021,https://www.nature.com/articles/s41586-021-03495-2></ref>. Glutamate is the main neurotransmitter in the brain and activates 8 different types of metabotropic glutamate receptors<ref name="Seven">Seven, Alpay B., et al. “G-Protein Activation by a Metabotropic Glutamate Receptor.” Nature News, Nature Publishing Group, 30 June 2021, https://www.nature.com/articles/s1586-021-03680-3</ref>[https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_2 Metabotropic Glutamate Receptor 2](mGlu2) is a member of the Class C GPCR Family and can further be classified into the Group II subgroup of metabotropic receptors. Since mGlu2 is a part of the Class C GPCR family, it undergoes small conformational changes to the transmembrane domain (TMD) to move from the inactive to the fully active structure<ref name="Lin" />. Functionality of mGlu2 will be dependent on the concentration of glutamate. Higher concentrations of glutamate will promote stronger signal transduction from the extracellular domain to the transmembrane domain.
+Metabotropic glutamate receptors are found in the central nervous system and play a critical role in modulating cell excitability and synaptic transmission<ref name="Lin">Lin, Shuling, et al. “Structures of GI-Bound Metabotropic Glutamate Receptors mglu2 and mglu4.” Nature News, Nature Publishing Group, 16 June 2021,https://www.nature.com/articles/s41586-021-03495-2></ref>. Glutamate is the main neurotransmitter in the brain and activates 8 different types of metabotropic glutamate receptors<ref name="Seven">Seven, Alpay B., et al. “G-Protein Activation by a Metabotropic Glutamate Receptor.” Nature News, Nature Publishing Group, 30 June 2021, https://www.nature.com/articles/s1586-021-03680-3</ref>.
+ [https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_2 Metabotropic Glutamate Receptor 2](mGlu2) is a member of the Class C GPCR Family and can further be classified into the Group II subgroup of metabotropic receptors. Since mGlu2 is a part of the Class C GPCR family, it undergoes small conformational changes to the transmembrane domain (TMD) to move from the inactive to the fully active structure<ref name="Lin" />. Functionality of mGlu2 will be dependent on the concentration of glutamate. Higher concentrations of glutamate will promote stronger signal transduction from the extracellular domain to the transmembrane domain.
 mGlu2 plays vital roles in memory formation, pain management, and addiction, which makes it an important drug target for Parkinson’s Disease<ref name="Zhang">Zhang, Zhu, et al. “Roles of Glutamate Receptors in Parkinson's Disease.” MDPI, Multidisciplinary Digital Publishing Institute, 6 Sept. 2019, https://dx.doi.org/10.3390%2Fijms20184391.></ref>, Schizophrenia (blue link), Cocaine Addiction<ref name="Yang">Yang, Hong-Ju, et al. “Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.” Cell Reports, U.S. National Library of Medicine, 11 July 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555082/.></ref>, and many other neurological conditions.