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'''STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX''' | '''STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX''' | ||
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[[Category: Weinzierl, R O.J.]] | [[Category: Weinzierl, R O.J.]] | ||
[[Category: Werner, F.]] | [[Category: Werner, F.]] | ||
[[Category: | [[Category: Dna-directed rna polymerase]] | ||
[[Category: | [[Category: Transcription]] | ||
[[Category: | [[Category: Transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:48:38 2008'' | |||
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Revision as of 17:48, 2 May 2008
STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX
OverviewOverview
The eukaryotic subunits RPB4 and RPB7 form a heterodimer that reversibly associates with the RNA polymerase II core and constitute the only two components of the enzyme for which no structural information is available. We have determined the crystal structure of the complex between the Methanococcus jannaschii subunits E and F, the archaeal homologs of RPB7 and RPB4. Subunit E has an elongated two-domain structure and contains two potential RNA binding motifs, while the smaller F subunit wraps around one side of subunit E, at the interface between the two domains. We propose a model for the interaction between RPB4/RPB7 and the core RNA polymerase in which the RNA binding face of RPB7 is positioned to interact with the nascent RNA transcript.
About this StructureAbout this Structure
1GO3 is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
ReferenceReference
Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex., Todone F, Brick P, Werner F, Weinzierl RO, Onesti S, Mol Cell. 2001 Nov;8(5):1137-43. PMID:11741548 Page seeded by OCA on Fri May 2 17:48:38 2008