3hcb: Difference between revisions

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==Crystal Structure of hPNMT in Complex With Noradrenochrome and AdoHcy==
==Crystal Structure of hPNMT in Complex With Noradrenochrome and AdoHcy==
<StructureSection load='3hcb' size='340' side='right' caption='[[3hcb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3hcb' size='340' side='right'caption='[[3hcb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HCB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hcb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HCB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LT2:(3S)-3-HYDROXY-2,3-DIHYDRO-1H-INDOLE-5,6-DIONE'>LT2</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LT2:(3S)-3-HYDROXY-2,3-DIHYDRO-1H-INDOLE-5,6-DIONE'>LT2</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hnn|1hnn]], [[1n7i|1n7i]], [[1n7j|1n7j]], [[1yz3|1yz3]], [[2an3|2an3]], [[2an5|2an5]], [[2an4|2an4]], [[2g70|2g70]], [[2ony|2ony]], [[2g71|2g71]], [[2g72|2g72]], [[2onz|2onz]], [[2obf|2obf]], [[2opb|2opb]], [[2g8n|2g8n]], [[3hca|3hca]], [[3hcc|3hcc]], [[3hcd|3hcd]], [[3hce|3hce]], [[3hcf|3hcf]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hnn|1hnn]], [[1n7i|1n7i]], [[1n7j|1n7j]], [[1yz3|1yz3]], [[2an3|2an3]], [[2an5|2an5]], [[2an4|2an4]], [[2g70|2g70]], [[2ony|2ony]], [[2g71|2g71]], [[2g72|2g72]], [[2onz|2onz]], [[2obf|2obf]], [[2opb|2opb]], [[2g8n|2g8n]], [[3hca|3hca]], [[3hcc|3hcc]], [[3hcd|3hcd]], [[3hce|3hce]], [[3hcf|3hcf]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hcb OCA], [http://pdbe.org/3hcb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hcb RCSB], [http://www.ebi.ac.uk/pdbsum/3hcb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hcb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hcb OCA], [https://pdbe.org/3hcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hcb RCSB], [https://www.ebi.ac.uk/pdbsum/3hcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hcb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.  
[[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Phenylethanolamine N-methyltransferase]]
[[Category: Phenylethanolamine N-methyltransferase]]
[[Category: Drinkwater, N]]
[[Category: Drinkwater, N]]

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