3h89: Difference between revisions
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==A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 4)== | ==A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 4)== | ||
<StructureSection load='3h89' size='340' side='right' caption='[[3h89]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3h89' size='340' side='right'caption='[[3h89]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3h89]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3h89]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H89 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NSX:N~2~,N~6~-BIS(BIPHENYL-4-YLACETYL)-L-LYSYL-D-ARGINYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>NSX</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NSX:N~2~,N~6~-BIS(BIPHENYL-4-YLACETYL)-L-LYSYL-D-ARGINYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>NSX</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3h8b|3h8b]], [[3h8c|3h8c]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h8b|3h8b]], [[3h8c|3h8c]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Catehpsin L ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Catehpsin L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h89 OCA], [https://pdbe.org/3h89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h89 RCSB], [https://www.ebi.ac.uk/pdbsum/3h89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h89 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Cathepsin|Cathepsin]] | *[[Cathepsin 3D structures|Cathepsin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Cathepsin L]] | [[Category: Cathepsin L]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Chowdhury, S F]] | [[Category: Chowdhury, S F]] | ||
[[Category: Joseph, L]] | [[Category: Joseph, L]] | ||