1gmj: Difference between revisions

Revision as of 17:45, 2 May 2008

THE STRUCTURE OF BOVINE IF1, THE REGULATORY SUBUNIT OF MITOCHONDRIAL F-ATPASE

OverviewOverview

In mitochondria, the hydrolytic activity of ATP synthase is regulated by an inhibitor protein, IF(1). Its binding to ATP synthase depends on pH, and below neutrality, IF(1) is dimeric and forms a stable complex with the enzyme. At higher pH values, IF(1) forms tetramers and is inactive. In the 2.2 A structure of the bovine IF(1) described here, the four monomers in the asymmetric unit are arranged as a dimer of dimers. Monomers form dimers via an antiparallel alpha-helical coiled coil in the C-terminal region. Dimers are associated into oligomers and form long fibres in the crystal lattice, via coiled-coil interactions in the N-terminal and inhibitory regions (residues 14-47). Therefore, tetramer formation masks the inhibitory region, preventing IF(1) binding to ATP synthase.

About this StructureAbout this Structure

1GMJ is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of bovine IF(1), the regulatory subunit of mitochondrial F-ATPase., Cabezon E, Runswick MJ, Leslie AG, Walker JE, EMBO J. 2001 Dec 17;20(24):6990-6. PMID:11742976 Page seeded by OCA on Fri May 2 17:45:12 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 '''THE STRUCTURE OF BOVINE IF1, THE REGULATORY SUBUNIT OF MITOCHONDRIAL F-ATPASE'''
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 [[Category: Runswick, M J.]]
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-[[Category: atp hydrolysis]]
+[[Category: Atp hydrolysis]]
-[[Category: bovine f1-atpase inhibitor protein]]
+[[Category: Bovine f1-atpase inhibitor protein]]
-[[Category: coiled-coil structure]]
+[[Category: Coiled-coil structure]]
-[[Category: p dependent oligomerization]]
+[[Category: P dependent oligomerization]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:45:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:47:02 2008''