1ghq: Difference between revisions

Revision as of 17:34, 2 May 2008

CR2-C3D COMPLEX STRUCTURE

OverviewOverview

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

About this StructureAbout this Structure

1GHQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:11387479 Page seeded by OCA on Fri May 2 17:34:29 2008

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OCA

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 [[Image:1ghq.jpg|left|200px]]
- {{Structure
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-}}
 '''CR2-C3D COMPLEX STRUCTURE'''
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 [[Category: Li, D.]]
 [[Category: Szakonyi, G.]]
-[[Category: c3d]]
+[[Category: C3d]]
-[[Category: cr2]]
+[[Category: Cr2]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:34:29 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:44:11 2008''