MAPK/ERK pathway: Difference between revisions
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====MAPK phosphorylates and activates MNK, which, in turn, phosphorylates CREB. The activated CREB protein then binds to a CRE region, and is then bound to by CBP ([[CREB-binding protein]]), which coactivates it, allowing it to switch certain genes on or off. CBP is a transcription activator.==== | ====MAPK phosphorylates and activates MNK, which, in turn, phosphorylates CREB. The activated CREB protein then binds to a CRE region, and is then bound to by CBP ([[CREB-binding protein]]), which coactivates it, allowing it to switch certain genes on or off. CBP is a transcription activator.==== | ||
Genes whose transcription is regulated by CREB include: ''c-fos'', BDNF, [[tyrosine hydroxylase]], numerous [[neuropeptides]] (such as somatostatin, [[enkephalin]], | Genes whose transcription is regulated by CREB include: ''c-fos'', BDNF, [[tyrosine hydroxylase]], numerous [[neuropeptides]] (such as somatostatin, [[enkephalin]], VGF, [[corticotropin-releasing hormone]]), and genes involved in the mammalian [[circadian clock]] ([[PER1]], [[PER2]]). | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||