TGF beta signaling pathway: Difference between revisions

Revision as of 17:33, 16 February 2022

The TGF beta superfamily of ligands

Bone morphogenetic protein

BMP-7 see Student Projects for UMass Chemistry 423 Spring 2012-4.

TGF-beta receptor

TGF-β receptors (Transforming Growth Factor) (TGFR) are serine/threonine kinase receptors. They are involved in paracrine signaling and are found in many types of tissue. TGF-β ligands include bone morphogenetic proteins, growth and initiation factors, anti-Mullerian hormone, activin, nodal TGF-β^[1]. There are 3 types of TGFR:

TGFR I forms heteromeric complex with TGFR II when it is bound to TGF-β. The complex transduces the TGF-β signal from the cell surface to the cytoplasm by phosphorylating proteins which regulate the transcription of genes related to cell proliferation. TGFR I has high affinity for TGF-β1 and low affinity for TGF-β2.
TGFR II is a tumor suppressor transmembrane protein. TGFR II has high affinity for TGF-β1 and low affinity for TGF-β2.
TGFR III is a cell-surface chondroitin sulfate / heparin sulfate proteoglycan. It acts as a reservoir of ligand for TGFRs. TGFR III has high affinity for TGF-β1, TGF-β2 and TGF-β1.2.

Human hTGFR-II extracellular domain (green) complex with TGF-β3 (grey) (PDB code 1ktz)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Wrana JL. TGF-beta receptors and signalling mechanisms. Miner Electrolyte Metab. 1998;24(2-3):120-30. PMID:9525694

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Alexander Berchansky

[1] Wrana JL. TGF-beta receptors and signalling mechanisms. Miner Electrolyte Metab. 1998;24(2-3):120-30. PMID:9525694

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 <StructureSection load='1ktz' size='340' side='right' caption='Human hTGFR-II extracellular domain (green) complex with TGF-β3 (grey) (PDB code [[1ktz]])' scene=''>
+==The TGF beta superfamily of ligands==
+===Bone morphogenetic protein===
+[[Bone morphogenetic protein]]
+BMP-7 see [[Student Projects for UMass Chemistry 423 Spring 2012-4]].
 ==[[TGF-beta receptor]]==
 '''TGF-β receptors''' (Transforming Growth Factor) (TGFR) are serine/threonine kinase receptors.  They are involved in paracrine signaling and are found in many types of tissue.  TGF-β ligands include bone morphogenetic proteins, growth and initiation factors, anti-Mullerian hormone, activin, nodal TGF-β<ref>PMID:9525694</ref>. There are 3 types of TGFR:     <br />