3e9y: Difference between revisions

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==Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron==
==Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron==
<StructureSection load='3e9y' size='340' side='right' caption='[[3e9y]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3e9y' size='340' side='right'caption='[[3e9y]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3e9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E9Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[3e9y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E9Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MS:N-[(4-METHYLPYRIMIDIN-2-YL)CARBAMOYL]-2-NITROBENZENESULFONAMIDE'>1MS</scene>, <scene name='pdbligand=FAB:FLAVIN-ADENINE+DINUCLEOTIDE-N5-ISOBUTYL+KETONE'>FAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=TDM:2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TDM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MS:N-[(4-METHYLPYRIMIDIN-2-YL)CARBAMOYL]-2-NITROBENZENESULFONAMIDE'>1MS</scene>, <scene name='pdbligand=FAB:FLAVIN-ADENINE+DINUCLEOTIDE-N5-ISOBUTYL+KETONE'>FAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=TDM:2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TDM</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ea4|3ea4]], [[1n0h|1n0h]], [[1t9a|1t9a]], [[1t9b|1t9b]], [[1t9c|1t9c]], [[1ybh|1ybh]], [[1yhy|1yhy]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ea4|3ea4]], [[1n0h|1n0h]], [[1t9a|1t9a]], [[1t9b|1t9b]], [[1t9c|1t9c]], [[1ybh|1ybh]], [[1yhy|1yhy]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSR 1.2, At3g48560, T8P19.70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSR 1.2, At3g48560, T8P19.70 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetolactate_synthase Acetolactate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.6 2.2.1.6] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetolactate_synthase Acetolactate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.6 2.2.1.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9y OCA], [http://pdbe.org/3e9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e9y RCSB], [http://www.ebi.ac.uk/pdbsum/3e9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9y OCA], [https://pdbe.org/3e9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e9y RCSB], [https://www.ebi.ac.uk/pdbsum/3e9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ILVB_ARATH ILVB_ARATH]] Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis.<ref>PMID:16665813</ref> <ref>PMID:2336405</ref> [:]<ref>PMID:16667374</ref> <ref>PMID:16668488</ref> <ref>PMID:8913312</ref> <ref>PMID:9355748</ref> <ref>PMID:9677339</ref> <ref>PMID:10386618</ref>   
[[https://www.uniprot.org/uniprot/ILVB_ARATH ILVB_ARATH]] Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis.<ref>PMID:16665813</ref> <ref>PMID:2336405</ref> [:]<ref>PMID:16667374</ref> <ref>PMID:16668488</ref> <ref>PMID:8913312</ref> <ref>PMID:9355748</ref> <ref>PMID:9677339</ref> <ref>PMID:10386618</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Acetolactate synthase]]
[[Category: Acetolactate synthase]]
[[Category: Arath]]
[[Category: Arath]]
[[Category: Large Structures]]
[[Category: Duggleby, R G]]
[[Category: Duggleby, R G]]
[[Category: Guddat, L W]]
[[Category: Guddat, L W]]

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