Retroviral integrase 3D structures: Difference between revisions
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*Human spumaretrovirus integrase | *Human spumaretrovirus integrase | ||
**[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]], [[4e7j]], [[4e7k]], [[4e7l]], [[5uoq]], [[5uop]], [[5no1]], [[5mmb]], [[5mma]], [[5fro]], [[5frm]], [[4ztj]], [[4ztf]] – | **[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]], [[4e7j]], [[4e7k]], [[4e7l]], [[5uoq]], [[5uop]], [[5no1]], [[5mmb]], [[5mma]], [[5fro]], [[5frm]], [[4ztj]], [[4ztf]] – intasome – human spumaretrovirus<br /> | ||
**[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – | **[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]], [[7adu]], [[7adv]] – intasome + inhibitor<br /> | ||
**[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain | **[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain<br /> | ||
**[[6rny]] – intasome + nucleosome – Cryo EM<br /> | |||
*Bovine immunodeficiency virus integrase | *Bovine immunodeficiency virus integrase | ||
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*Human immunodeficiency virus 1 integrase; Domains – N-terminal zinc-binding 728-773; catalytic core 50-212; C-terminal 219-273; C-terminal DBD 947-997; CCD 1197-1359 | *Human immunodeficiency virus 1 integrase; Domains – N-terminal zinc-binding 728-773; catalytic core 50-212; C-terminal 219-273; C-terminal DBD 947-997; CCD 1197-1359 | ||
**[[6u8q]], [[6vdk]] – | **[[6u8q]], [[6vdk]] – intasome – Cryo EM <br /> | ||
**[[5oi5]], [[5oi3]], [[5oi2]], [[1itg]], [[6jcg]], [[6jcf]], [[6vrg]] – IN catalytic core domain <br /> | **[[5oi5]], [[5oi3]], [[5oi2]], [[1itg]], [[6jcg]], [[6jcf]], [[6vrg]] – IN catalytic core domain <br /> | ||
**[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]], [[5jl4]], [[6l0c]] - IN catalytic core domain (mutant) – HIV-1<br /> | **[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]], [[5jl4]], [[6l0c]], [[6vrg]] - IN catalytic core domain (mutant) – HIV-1<br /> | ||
**[[6t6e]], [[6t6i]], [[6t6j]] – IN catalytic C-terminal domain <br /> | |||
**[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br /> | **[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br /> | ||
**[[1k6y]] - IN N-terminal + catalytic core domain<br /> | **[[1k6y]] - IN N-terminal + catalytic core domain<br /> | ||
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**[[1qmc]] – IN DBD - NMR<br /> | **[[1qmc]] – IN DBD - NMR<br /> | ||
**[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]], [[1qs4]] - IN CCD domain (mutant) + lens epithelium-derived growth factor <br /> | **[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]], [[1qs4]] - IN CCD domain (mutant) + lens epithelium-derived growth factor <br /> | ||
**[[6ex9]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[4o0j]], [[1hyv]], [[1hyz]], [[6um8]], [[6vlm]] – IN catalytic core domain + inhibitor <br /> | **[[6ex9]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[4o0j]], [[1hyv]], [[1hyz]], [[6um8]], [[6vlm]], [[6vkh]], [[6vlh]], [[6vlm]], [[6vqs]], [[6vx2]], [[6w0u]], [[6w42]], [[6wc8]], [[6we7]], [[7d83]] – IN catalytic core domain + inhibitor <br /> | ||
**[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]], [[4ojr]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[5hot]], [[4tsx]], [[4ovl]], [[4ojr]], [[4o5b]], [[4o55]], [[4nyf]], [[6nuj]], [[6ncj]], [[6eb2]], [[6eb1]], [[6lmi]], [[6lmq]], [[6ncj]], [[6nuj]] - IN core domain (mutant) + inhibitor<br /> | **[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]], [[4ojr]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[5hot]], [[4tsx]], [[4ovl]], [[4ojr]], [[4o5b]], [[4o55]], [[4nyf]], [[6nuj]], [[6ncj]], [[6eb2]], [[6eb1]], [[6lmi]], [[6lmq]], [[6ncj]], [[6nuj]] - IN core domain (mutant) + inhibitor<br /> | ||
**[[5tc2]] – IN C terminal <br /> | **[[5tc2]] – IN C terminal <br /> | ||
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**[[6qbv]], [[6qbw]] – IN catalytic core domain <br /> | **[[6qbv]], [[6qbw]] – IN catalytic core domain <br /> | ||
**[[6tju]] – IN C-terminal domain <br /> | |||
*Moloney murine leukemia virus integrase | *Moloney murine leukemia virus integrase | ||
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**[[5t3a]] – IN <br /> | **[[5t3a]] – IN <br /> | ||
**[[5llj]] – IN C terminal<br /> | **[[5llj]] – IN C terminal<br /> | ||
**[[5m0r]], [[5m0q]] – | **[[5m0r]], [[5m0q]] – intasome – Cryo EM<br /> | ||
*Simian immunodeficiency virus integrase | *Simian immunodeficiency virus integrase | ||
**[[1c6v]] – IN catalytic domain + DNA binding domain - SIV | **[[1c6v]] – IN catalytic domain (mutant) + DNA binding domain - SIV <br /> | ||
**[[6rwl]] – intasome – Cryo EM<br /> | |||
**[[6rwo]] – intasome (mutant) + drug – Cryo EM<br /> | |||
*Simian T-cell lymphotropic virus | |||
**[[6rwl]] – intasome + PP2A regulatory subunit – Cryo EM<br /> | |||
*Feline immunodeficiency virus integrase | *Feline immunodeficiency virus integrase | ||
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**[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br /> | **[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br /> | ||
**[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor<br /> | **[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor<br /> | ||
**[[5ejk]] – | **[[5ejk]] – intasome + gag-pro-pol polyprotein <br /> | ||
**[[7ku7]], [[7kui]] – intasome – Cryo EM<br /> | |||
**[[7jn3]] – intasome (mutant) + drug – Cryo EM<br /> | |||
*Avian sarcoma virus integrase | *Avian sarcoma virus integrase | ||