1ga3: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1ga3.jpg|left|200px]] | [[Image:1ga3.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1ga3", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_1ga3| PDB=1ga3 | SCENE= }} | |||
| | |||
}} | |||
'''NMR STRUCTURE OF INTERLEUKIN-13''' | '''NMR STRUCTURE OF INTERLEUKIN-13''' | ||
| Line 32: | Line 29: | ||
[[Category: Eisenmesser, E Z.]] | [[Category: Eisenmesser, E Z.]] | ||
[[Category: Horita, D A.]] | [[Category: Horita, D A.]] | ||
[[Category: | [[Category: Interleukin-13,il-13,il13,cytokine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:20:11 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:20, 2 May 2008
NMR STRUCTURE OF INTERLEUKIN-13
OverviewOverview
The complex and interrelated function of the interleukin cytokines relies on a range of pro-inflammatory and anti-inflammatory immune responses mediated by an array of receptors, and there is considerable cross-reactivity for related cytokines. Recent findings continue to elucidate the expression patterns of interleukin receptors associated with a range of diseases, including cancer. We report here the first experimentally determined high-resolution structure of human interleukin-13 (IL-13). The experimental structure is significantly different from an earlier homology model, which could have led to improper estimation of receptor interaction surfaces and design of mutational experiments. Similarities between the presented IL-13 structure and the homologous interleukin-4 (IL-4) are discussed. Additionally, mutation data for IL-4 and IL-13 are analyzed and combined with a detailed structural analysis of the IL-4/IL4Ralpha interface that leads us to postulate interactions at the IL-13/receptor interface. The structural comparison is used to interpret the different affinities for various receptors and establishes the basis for further mutational experiments and antagonist design.
DiseaseDisease
Known disease associated with this structure: Allergic rhinitis, susceptibility to OMIM:[147683], Asthma, susceptibility to OMIM:[147683]
About this StructureAbout this Structure
1GA3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of interleukin-13 and insights into receptor engagement., Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA, J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:11419949 Page seeded by OCA on Fri May 2 17:20:11 2008