3c9a: Difference between revisions

<StructureSection load='3c9a' size='340' side='right' caption='[[3c9a]], [[Resolution|resolution]] 1.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[3c9a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C9A FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ca7|3ca7]], [[3cgu|3cgu]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">argos, Aos, gil, sty ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]), spi ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c9a OCA], [http://pdbe.org/3c9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c9a RCSB], [http://www.ebi.ac.uk/pdbsum/3c9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c9a ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GIL_DROME GIL_DROME]] Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi).<ref>PMID:1628618</ref> <ref>PMID:1606617</ref> <ref>PMID:1286772</ref> <ref>PMID:10200472</ref> <ref>PMID:15329724</ref> <ref>PMID:15879554</ref>  [[http://www.uniprot.org/uniprot/SPITZ_DROME SPITZ_DROME]] Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.<ref>PMID:7833286</ref>   

     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c9a_consurf.spt"</scriptWhenChecked>