Ubiquitin and Ubiquitination: Difference between revisions

<StructureSection load='1UBQ' size='340' side='right' caption='Structure of Ubiquitin refined' scene=''>

Discovered in 1975 by researchers led by Gideon Goldstein. Ubiquitin was found by research that was funded to characterize proteins and associated processes. Aaron Ciechanover, Avram Hershko, and Irwin Rose extended Ubiquitin's acknowledgment by relating it to cell cycle control of biological processes, including gene transcription and immune functionalization. Ubiquitin is a small protein modifier in the sense that it is more associated with being a post-transitional modifier. On a general basis, Ubiquitin is found in tissues of humans and eukaryotic organisms. It is well known for the role that it plays in protein apoptosis. It is commonly known as the “kiss of death” for proteins in the body even though Ubiquitin is primarily associated with adjusting proteins in binding and functions. Ubiquitin is found in the nucleus and can be seen in the cytoplasm and cell surface membrane. Ubiquitin can handle a spectrum of pH ranges and can also resist tryptic digestion.