LRRK2: Difference between revisions
New page: ==Parkinson's disease== <p>Parkinson’s disease (PD) is a gradually worsening brain disease accompanied by stiffness, shaking, fatigue, memory difficulties, behavioural changes and proble... |
Michal Harel (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
== LRRK2 == | == LRRK2 == | ||
<p>This multidomain protein called LRRK2 or dardarin is a product of LRRK2 gene. Its abbreviation stands for leucine rich repeat kinase 2 and it belongs to ROCO protein family. Although its precise function is unknown, it is proposed that LRRK2 interacts with microtubules, phosphorylates Rab GTPase which marks membranous cargos moving along the microtubules, phosphorylates β-tubulin, moesin, FoxO1, tau, and others <ref>PMID:24725412</ref>. The cargo might be implicated in pathology of Parkinson´s disease <ref>PMID: 27830778</ref>.</p> | <p>This multidomain protein called '''LRRK2''' or '''dardarin''' is a product of LRRK2 gene. Its abbreviation stands for leucine rich repeat kinase 2 and it belongs to ROCO protein family. Although its precise function is unknown, it is proposed that LRRK2 interacts with microtubules, phosphorylates Rab GTPase which marks membranous cargos moving along the microtubules, phosphorylates β-tubulin, moesin, FoxO1, tau, and others <ref>PMID:24725412</ref>. The cargo might be implicated in pathology of Parkinson´s disease <ref>PMID: 27830778</ref>.</p> | ||
<p>LRRK2 is 2527 amino acids long protein in which we can distinguish N-terminus with scaffold domains such as armadillo, ankyrin, and leucin-rich repeats interaction motifs, and C-terminus with Ras-like GTPase (ROC domain controlling kinase activity of LRRK2), MAPKKK-like kinase domain, COR domain important for dimerization, and scaffold WD40 domain<ref>PMID: 32814344</ref>. LRRK2 has both GTPase and kinase activity, mediated by ROC domain and kinase domain, respectively, and the kinase activity is regulated by the ROC domain <ref name="sest">PMID: 17706965</ref>.</p> | <p>LRRK2 is 2527 amino acids long protein in which we can distinguish N-terminus with scaffold domains such as armadillo, ankyrin, and leucin-rich repeats interaction motifs, and C-terminus with Ras-like GTPase (ROC domain controlling kinase activity of LRRK2), MAPKKK-like kinase domain, COR domain important for dimerization, and scaffold WD40 domain<ref>PMID: 32814344</ref>. LRRK2 has both GTPase and kinase activity, mediated by ROC domain and kinase domain, respectively, and the kinase activity is regulated by the ROC domain <ref name="sest">PMID: 17706965</ref>.</p> | ||
<p>COR domain represents a central part in head-to-head orientation when LRRK2 folds into predominant form of globular dimer, where kinase-WD40 modul folds back to domains of N-terminus and thus allows these parts to interact and create autophosphorylation sites <ref name="guaitoli"/>.</p> | <p>COR domain represents a central part in head-to-head orientation when LRRK2 folds into predominant form of globular dimer, where kinase-WD40 modul folds back to domains of N-terminus and thus allows these parts to interact and create autophosphorylation sites <ref name="guaitoli"/>.</p> | ||