Pyrrolysine: Difference between revisions
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Pyrrolysine is a naturally-occurring, genetically encoded [[Amino Acids|amino acid]], sometimes called the "22nd amino acid". For more information, please see [http://en.wikipedia.org/wiki/Pyrrolysine Pyrrolysine in Wikipedia]. | Pyrrolysine is a naturally-occurring, genetically encoded [[Amino Acids|amino acid]], sometimes called the "22nd amino acid". For more information, please see [http://en.wikipedia.org/wiki/Pyrrolysine Pyrrolysine in Wikipedia]. | ||
==Occurrence== | ==Occurrence== | ||
In January, 2022, 7 [[wwPDB]] entries contain PYL. | |||
Some proteins in methanogenic archaea include '''[[Pyrrolysine|pyrrolysine (Pyl)]]'''. ''Methanosarcina barkeri'' monomethylamine methyltransferase (MtmB, [[1nth]], [[1l2q]]) was the first identified structure containing this amino acid, and in the crystal structure it is identified as BGX, with the rest of the amnio acid identified as LYS202<ref>PMID: 12029132</ref>. Chemically modified forms of pyrrolysine are present in the MtmB structures [[1tv2]], [[1tv3]], and [[1tv4]]<ref>PMID: 15380192</ref>. The [[PDB]] also contains several structures for pyrrolysyl-tRNA synthetase, including [[2zce]] which includes pyrrolysine designated PYH. | Some proteins in methanogenic archaea include '''[[Pyrrolysine|pyrrolysine (Pyl)]]'''. ''Methanosarcina barkeri'' monomethylamine methyltransferase (MtmB, [[1nth]], [[1l2q]]) was the first identified structure containing this amino acid, and in the crystal structure it is identified as BGX, with the rest of the amnio acid identified as LYS202<ref>PMID: 12029132</ref>. Chemically modified forms of pyrrolysine are present in the MtmB structures [[1tv2]], [[1tv3]], and [[1tv4]]<ref>PMID: 15380192</ref>. The [[PDB]] also contains several structures for pyrrolysyl-tRNA synthetase, including [[2zce]] which includes pyrrolysine designated PYH. | ||