NADPH oxidase: Difference between revisions
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NADPH oxidase is associated with diseases, an example involves a mutation in the gene that encodes the NADPH oxidase complex, this mutation can cause chronic granulomatous disease. Chronic granulomatous disease is an uncommon immunodeficiency disease that is inherited from through X-linked recessive or autosomal recessive pathways. Through the mutations, there is a reduction in Nox2 expression that leads to deficiencies in phagocyte function. Another disease that is impacted by NADPH oxidase is stroke, stroke in general is caused by the exhaustion of oxygen and the input of oxygen. Higher levels of reactive oxygen species has been shown to have a significant impact on stroke. Nox2 and Nox4 are the common forms of NADPH oxidase that are associated with superoxide formation and pathology in stroke. NADPH oxidase is important for neutrotoxic components after microglia activation. During stroke it is shown that there is an increase in Nox2 levels and superoxide formation. Multiple sclerosis also has NADPH oxidase involvement. Multiple Sclerosis is another autoimmune disease that results in demyelination and neurodegeneration in humans. The production of superoxides is vital in multiple sclerosis pathogenesis. Research also presented that Nox2 is upregulated in microglia, this represents that activated microglia can aid in the formation of reactive oxygen species. | NADPH oxidase is associated with diseases, an example involves a mutation in the gene that encodes the NADPH oxidase complex, this mutation can cause chronic granulomatous disease. Chronic granulomatous disease is an uncommon immunodeficiency disease that is inherited from through X-linked recessive or autosomal recessive pathways. Through the mutations, there is a reduction in Nox2 expression that leads to deficiencies in phagocyte function. Another disease that is impacted by NADPH oxidase is stroke, stroke in general is caused by the exhaustion of oxygen and the input of oxygen. Higher levels of reactive oxygen species has been shown to have a significant impact on stroke. Nox2 and Nox4 are the common forms of NADPH oxidase that are associated with superoxide formation and pathology in stroke. NADPH oxidase is important for neutrotoxic components after microglia activation. During stroke it is shown that there is an increase in Nox2 levels and superoxide formation. Multiple sclerosis also has NADPH oxidase involvement. Multiple Sclerosis is another autoimmune disease that results in demyelination and neurodegeneration in humans. The production of superoxides is vital in multiple sclerosis pathogenesis. Research also presented that Nox2 is upregulated in microglia, this represents that activated microglia can aid in the formation of reactive oxygen species. | ||
[[Image:Diabetes NADPH.jpeg]] | [[Image:Diabetes NADPH.jpeg]] | ||
==3D structures of NADPH oxidase== | ==3D structures of NADPH oxidase== | ||
[[NADPH oxidase 3D structures]] | [[NADPH oxidase 3D structures]] | ||
</StructureSection> | |||
== References == | == References == | ||