Epithelial discoidin domain-containing receptor: Difference between revisions
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'''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing [[Receptor tyrosine kinases]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>. | '''Epithelial discoidin domain-containing receptor''' (DDR1 and DDR2) are extracellular matrix-sensing [[Receptor tyrosine kinases]] which are activated by collagen and are expressed in bronchial epithelium. They are responsible for maintaining the normal structure of skin and kidney epithelia<ref>PMID:20884741</ref>. DDR1 and DDR2 function as sensors for extracellular matrix and to regulate a wide range of cell functions from migration and proliferation to cytokine secretion and extracellular matrix homeostasis/remodeling<ref name = "DDR1">PMID:24361528</ref>. | ||
See also [[Kinase-linked, enzyme-linked and related receptors]]. | |||
== Disease == | == Disease == | ||