2jry: Difference between revisions

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 <StructureSection load='2jry' size='340' side='right'caption='[[2jry]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_radiatus Conus radiatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JRY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_radiatus Conus radiatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRY FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jry OCA], [http://pdbe.org/2jry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jry RCSB], [http://www.ebi.ac.uk/pdbsum/2jry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jry ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jry OCA], [https://pdbe.org/2jry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jry RCSB], [https://www.ebi.ac.uk/pdbsum/2jry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jry ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>
+[[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]