Enkephalin: Difference between revisions
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The second approach to increase enkephalin stability ''in-vivo'' is the '''blocking of the peptidases''' themselves, such as enkephalinase and aminopeptidase. One example is DENKIs <ref name="cullen"/>.Dual Enkephalinase Inhibitors (DENKIs) are a novel therapeutic approach for opioid use disorders. This class of compounds physiologically activates the endogenous opioid system by inhibiting the enzymes responsible for the breakdown of enkephalins, protecting endogenous enkephalins, increasing their half-lives and physiological actions <ref>Alvarez-Perez, B, Poras, H, Maldonado, R. THE INHIBITION OF ENKEPHALIN CATABOLISM BY DUAL ENKEPHALINASE INHIBITOR: A NOVEL POSSIBLE THERAPEUTIC APPROACH FOR OPIOID USE DISORDERS. Br J Pharmacol. 2021. Accepted Author Manuscript. https://doi.org/10.1111/bph.15656</ref>. | The second approach to increase enkephalin stability ''in-vivo'' is the '''blocking of the peptidases''' themselves, such as enkephalinase and aminopeptidase. One example is DENKIs <ref name="cullen"/>.Dual Enkephalinase Inhibitors (DENKIs) are a novel therapeutic approach for opioid use disorders. This class of compounds physiologically activates the endogenous opioid system by inhibiting the enzymes responsible for the breakdown of enkephalins, protecting endogenous enkephalins, increasing their half-lives and physiological actions <ref>Alvarez-Perez, B, Poras, H, Maldonado, R. THE INHIBITION OF ENKEPHALIN CATABOLISM BY DUAL ENKEPHALINASE INHIBITOR: A NOVEL POSSIBLE THERAPEUTIC APPROACH FOR OPIOID USE DISORDERS. Br J Pharmacol. 2021. Accepted Author Manuscript. https://doi.org/10.1111/bph.15656</ref>. | ||
== [[Enkephalin 3D structures]] | == [[Enkephalin 3D structures]]== | ||
== References == | == References == | ||
<references/> | <references/> | ||