2c9f: Difference between revisions

<table><tr><td colspan='2'>[[2c9f]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Ade02 Ade02] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_2 Human adenovirus type 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2C9F FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x9p|1x9p]], [[1x9t|1x9t]], [[2bld|2bld]], [[2bvi|2bvi]], [[2c6s|2c6s]], [[2c9g|2c9g]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2c9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9f OCA], [http://pdbe.org/2c9f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c9f RCSB], [http://www.ebi.ac.uk/pdbsum/2c9f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c9f ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CAPSP_ADE02 CAPSP_ADE02]] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.<ref>PMID:12221069</ref> <ref>PMID:20615244</ref> <ref>PMID:20798312</ref>