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==Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina== | ==Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina== | ||
<StructureSection load='6ubl' size='340' side='right'caption='[[6ubl]]' scene=''> | <StructureSection load='6ubl' size='340' side='right'caption='[[6ubl]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UBL OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6ubl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_53710 Atcc 53710]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UBL FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GA0070603_4197 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47854 ATCC 53710])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ubl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ubl OCA], [https://pdbe.org/6ubl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ubl RCSB], [https://www.ebi.ac.uk/pdbsum/6ubl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ubl ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Dynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster to decipher their roles in assembling this unique molecule. This paper reports the crystal structure of DynF, the gene product of one of the genes within the biosynthetic gene cluster of dynemicin. DynF is revealed to be a dimeric eight-stranded beta-barrel structure with palmitic acid bound within a cavity. The presence of palmitic acid suggests that DynF may be involved in binding the precursor polyene heptaene, which is central to the synthesis of the ten-membered ring of the enediyne core. | |||
The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.,Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr Acta Crystallogr F Struct Biol Commun. 2022 Jan 1;78(Pt 1):1-7. doi:, 10.1107/S2053230X21012322. Epub 2022 Jan 1. PMID:34981769<ref>PMID:34981769</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6ubl" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Atcc 53710]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bhardwaj M]] | [[Category: Bhardwaj, M]] | ||
[[Category: Kosgei | [[Category: Kosgei, A J]] | ||
[[Category: Miller | [[Category: Lanen, S G.Van]] | ||
[[Category: Phillips | [[Category: Miller, M D]] | ||
[[Category: Thorson | [[Category: Phillips, G N]] | ||
[[Category: | [[Category: Thorson, J S]] | ||
[[Category: | [[Category: Xu, W]] | ||
[[Category: Beta barrel]] | |||
[[Category: Dynemicin biosynthesis]] | |||
[[Category: Enediyne biosynthetic pathway]] | |||
[[Category: Unknown function]] | |||
Revision as of 13:01, 12 January 2022
Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersinaStructure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina
Structural highlights
Publication Abstract from PubMedDynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster to decipher their roles in assembling this unique molecule. This paper reports the crystal structure of DynF, the gene product of one of the genes within the biosynthetic gene cluster of dynemicin. DynF is revealed to be a dimeric eight-stranded beta-barrel structure with palmitic acid bound within a cavity. The presence of palmitic acid suggests that DynF may be involved in binding the precursor polyene heptaene, which is central to the synthesis of the ten-membered ring of the enediyne core. The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.,Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr Acta Crystallogr F Struct Biol Commun. 2022 Jan 1;78(Pt 1):1-7. doi:, 10.1107/S2053230X21012322. Epub 2022 Jan 1. PMID:34981769[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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