1g2i: Difference between revisions

Revision as of 17:03, 2 May 2008

CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION

OverviewOverview

The intracellular protease from Pyrococcus horikoshii (PH1704) and PfpI from Pyrococcus furiosus are members of a class of intracellular proteases that have no sequence homology to any other known protease family. We report the crystal structure of PH1704 at 2.0-A resolution. The protease is tentatively identified as a cysteine protease based on the presence of cysteine (residue 100) in a nucleophile elbow motif. In the crystal, PH1704 forms a hexameric ring structure, and the active sites are formed at the interfaces between three pairs of monomers.

About this StructureAbout this Structure

1G2I is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution., Du X, Choi IG, Kim R, Wang W, Jancarik J, Yokota H, Kim SH, Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14079-84. PMID:11114201 Page seeded by OCA on Fri May 2 17:03:27 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1g2i.gif|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1g2i", creates the "Structure Box" on the page.
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-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= PH1704 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
+-->
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03134 GATase1_PfpI_like]</span>
+{{STRUCTURE_1g2i|  PDB=1g2i  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2i OCA], [http://www.ebi.ac.uk/pdbsum/1g2i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g2i RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION'''
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 [[Category: Kim, R.]]
 [[Category: Kim, S H.]]
-[[Category: atp-independent intracellular protease]]
+[[Category: Atp-independent intracellular protease]]
-[[Category: berkeley structural genomics center]]
+[[Category: Berkeley structural genomics center]]
-[[Category: bsgc structure funded by nih]]
+[[Category: Bsgc structure funded by nih]]
-[[Category: catalytical triad]]
+[[Category: Catalytical triad]]
-[[Category: cysteine protease]]
+[[Category: Cysteine protease]]
-[[Category: intracellular protease]]
+[[Category: Intracellular protease]]
-[[Category: nucleophile elbow]]
+[[Category: Nucleophile elbow]]
-[[Category: pfpi]]
+[[Category: Pfpi]]
-[[Category: protease]]
+[[Category: Protease]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi]]
+[[Category: Psi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:03:27 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:35:10 2008''