1g1r: Difference between revisions
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'''Crystal structure of P-selectin lectin/EGF domains complexed with SLeX''' | '''Crystal structure of P-selectin lectin/EGF domains complexed with SLeX''' | ||
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[[Category: Camphausen, R T.]] | [[Category: Camphausen, R T.]] | ||
[[Category: Somers, W S.]] | [[Category: Somers, W S.]] | ||
[[Category: | [[Category: Adhesion molecule]] | ||
[[Category: | [[Category: Egf]] | ||
[[Category: | [[Category: Lectin]] | ||
[[Category: | [[Category: Slex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:01:40 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:01, 2 May 2008
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| 1g1r, resolution 3.40Å () | |||||||||
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| Ligands: | , , , , | ||||||||
| Non-Standard Residues: | |||||||||
| Related: | 1g1q, 1g1s, 1g1t | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of P-selectin lectin/EGF domains complexed with SLeX
OverviewOverview
P-, E- and L-selectin constitute a family of cell adhesion receptors that mediate the initial tethering and rolling of leukocytes on inflamed endothelium as a prelude to their firm attachment and extravasation into tissues. The selectins bind weakly to sialyl Lewisx (SLe(X))-like glycans, but with high-affinity to specific glycoprotein counterreceptors, including PSGL-1. Here, we report crystal structures of human P- and E-selectin constructs containing the lectin and EGF (LE) domains co-complexed with SLe(X). We also present the crystal structure of P-selectin LE co-complexed with the N-terminal domain of human PSGL-1 modified by both tyrosine sulfation and SLe(X). These structures reveal differences in how E- and P-selectin bind SLe(X) and the molecular basis of the high-affinity interaction between P-selectin and PSGL-1.
About this StructureAbout this Structure
1G1R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1., Somers WS, Tang J, Shaw GD, Camphausen RT, Cell. 2000 Oct 27;103(3):467-79. PMID:11081633 Page seeded by OCA on Fri May 2 17:01:40 2008