Ca2+ signalling processes: Difference between revisions
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<StructureSection load='1n4K' size='350' side='right' caption='Mouse inositol triphosphate receptor ligand-binding core complex with its ligand inositol triphosphate (PDB entry [[1n4k]])' scene='38/382942/Cv/1'> | <StructureSection load='1n4K' size='350' side='right' caption='Mouse inositol triphosphate receptor ligand-binding core complex with its ligand inositol triphosphate (PDB entry [[1n4k]])' scene='38/382942/Cv/1'> | ||
*[[Inositol 1,4,5-Trisphosphate Receptor]] | *[[Inositol 1,4,5-Trisphosphate Receptor]] | ||
[[Inositol 1,4,5-Trisphosphate Receptor]] binding protein is a ubiquitous protein involved in the Ca<sup>2+</sup> signalling processes in a variety of organisms <ref name="mainpaper">PMID:12442173</ref> | [[Inositol 1,4,5-Trisphosphate Receptor]] binding protein is a ubiquitous protein involved in the Ca<sup>2+</sup> signalling processes in a variety of organisms <ref name="mainpaper">PMID:12442173</ref>. The specific type of inositol 1,4,5-trisphosphate receptor (InsP<sub>3</sub>R) protein discussed here is the mouse type 1 InsP<sub>3</sub>R, also called InsP<sub>3</sub>R1. This polypeptide contains three major regions: the <scene name='38/382942/N_terminal_domain/1'>amino terminal</scene> inositol 1,4,5-trisphosphate (InsP<sub>3</sub>) binding region, the central modulatory region, and the <scene name='38/382942/C_terminal_domain/1'>carboxy-terminus channel region</scene>.<ref name="mainpaper"/> The protein forms an L-shaped structure composed of two asymmetric domains perpendicular to each other.<ref name="mainpaper"/> The N-terminal domain is made up of 12 β-strands and 2 single-turn helices, which come together to form a barrel.<ref name="mainpaper"/> The C-terminal end is quite different, consisting of a bundle made of eight α-helices.<ref name="mainpaper"/> The interface of the two domains is lined with basic residues and forms the <scene name='38/382942/Ip3_binding_pocket/1'>receptor site</scene> for InsP<sub>3</sub>.<ref name="mainpaper"/> The InsP<sub>3</sub>R protein does not belong to a superfamily of proteins. The receptor is thought to span the membrane 6 times, leaving the C-terminus in the cytoplasm.<ref name="functionref"/> | ||
*[[Calcium-dependent protein kinase]] | *[[Calcium-dependent protein kinase]] | ||
*[[Calcium/Calmodulin-dependent protein kinase]] | *[[Calcium/Calmodulin-dependent protein kinase]] | ||