Phosphodiesterase 3D structures: Difference between revisions
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*PDE 3 | *PDE 3 | ||
**[[7l27]] – hPDE 3a <br /> | |||
**[[7l29]] – hPDE 3a + AMP <br /> | |||
**[[7kwe]] – hPDE 3a + DNMDP <br /> | |||
**[[7l28]] – hPDE 3a + trequinsin <br /> | |||
**[[7eg0]], [[7eg1]], [[7eg4]], [[7lrc]], [[7lrd]] – hPDE 3a + SLFN12 – Cryo EM <br /> | |||
**[[1so2]], [[1soj]] – hPDE 3b catalytic domain + inhibitor<br /> | **[[1so2]], [[1soj]] – hPDE 3b catalytic domain + inhibitor<br /> | ||
**[[5z7c]] – PDE 3 (mutant) – ''Vibrio cholerae'' <br /> | **[[5z7c]] – PDE 3 (mutant) – ''Vibrio cholerae'' <br /> | ||
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**[[1e9k]] - hPDE 4d5 N terminal – NMR<BR /> | **[[1e9k]] - hPDE 4d5 N terminal – NMR<BR /> | ||
**[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br /> | **[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br /> | ||
**[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]], [[6kjz]], [[6kk0]] - hPDE 4d catalytic domain + drug<br /> | **[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]], [[6akr]], [[6kjz]], [[6kk0]], [[6lrm]], [[7cbq]] - hPDE 4d catalytic domain + drug<br /> | ||
**[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR /> | **[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR /> | ||
**[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR /> | **[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR /> | ||
**[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]], [[5wqa]], [[5tkb]], [[5k32]], [[5k1i]], [[4wcu]], [[4w1o]], [[4ogb]], [[6fdc]], [[6f8x]], [[6f8w]], [[6f8v]], [[6f8u]], [[6f8t]], [[6f8r]], [[6f6u]], [[5wh6]], [[5wh5]], [[5lbo]], [[6rcw]], [[6inm]], [[6ink]], [[6ind]], [[6imt]], [[6imr]], [[6imo]], [[6imd]], [[6imi]], [[6imb]], [[6im6]], [[6hwo]], [[6fw3]], [[6ftw]], [[6fta]], [[6ft0]], [[6fet]], [[6feb]], [[6fe7]], [[6fdi]], [[6boj]], [[6iag]], [[6ibf]] - hPDE 4d catalytic domain + inhibitor<br /> | **[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]], [[5wqa]], [[5tkb]], [[5k32]], [[5k1i]], [[4wcu]], [[4w1o]], [[4ogb]], [[6fdc]], [[6f8x]], [[6f8w]], [[6f8v]], [[6f8u]], [[6f8t]], [[6f8r]], [[6f6u]], [[5wh6]], [[5wh5]], [[5lbo]], [[6rcw]], [[6inm]], [[6ink]], [[6ind]], [[6imt]], [[6imr]], [[6imo]], [[6imd]], [[6imi]], [[6imb]], [[6im6]], [[6hwo]], [[6fw3]], [[6ftw]], [[6fta]], [[6ft0]], [[6fet]], [[6feb]], [[6fe7]], [[6fdi]], [[6boj]], [[6iag]], [[6ibf]], [[6zba]], [[7a8q]], [[7a9v]], [[7aag]], [[7ab9]], [[7abd]], [[7abe]], [[7abj]], [[7ay6]], [[7b9h]], [[7cbj]], [[7k2k]], [[7f2l]], [[7f2m]] - hPDE 4d catalytic domain + inhibitor<br /> | ||
**[[6njj]], [[6nji]], [[6njh]] - hPDE 4d catalytic domain (mutant) + inhibitor<br /> | **[[6njj]], [[6nji]], [[6njh]] - hPDE 4d catalytic domain (mutant) + inhibitor<br /> | ||
**[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator | **[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator | ||
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**[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR /> | **[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR /> | ||
**[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br /> | **[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br /> | ||
**[[2chm]], [[4oex]], [[4oew]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]], [[4md6]], [[5jo3]], [[6acb]], [[5zz2]], [[6iwi]] - hPDE 5a catalytic domain + inhibitor<br /> | **[[2chm]], [[4oex]], [[4oew]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]], [[4md6]], [[5jo3]], [[6acb]], [[5zz2]], [[6iwi]], [[6vbi]] - hPDE 5a catalytic domain + inhibitor<br /> | ||
**[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br /> | **[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br /> | ||
**[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]], [[6l6e]] - hPDE 5 catalytic domain + drug<br /> | **[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]], [[6l6e]] - hPDE 5 catalytic domain + drug<br /> | ||
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**[[4jhp]] - hPDE 6d δ subunit + RPGR<br /> | **[[4jhp]] - hPDE 6d δ subunit + RPGR<br /> | ||
**[[4jv6]], [[4jv8]], [[4jvb]], [[4jvf]], [[5ml2]], [[5ml3]], [[5ml4]], [[5ml6]], [[5ml8]], [[5nal]], [[5e80]] - hPDE 6d δ subunit + inhibitor<br /> | **[[4jv6]], [[4jv8]], [[4jvb]], [[4jvf]], [[5ml2]], [[5ml3]], [[5ml4]], [[5ml6]], [[5ml8]], [[5nal]], [[5e80]] - hPDE 6d δ subunit + inhibitor<br /> | ||
**[[3dba]] - | **[[6mzb]], [[7jsn]] - bPDE 6 g subunit in visual signaling complex – Cryo EM<br /> | ||
**[[3dba]] - cPDE 6c GAF A domain – chicken<BR /> | |||
**[[6x88]] - cPDE 6c a subunit GAF domain 1-862<br /> | |||
*PDE 7 | *PDE 7 | ||
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**[[3ecm]] – hPDE 8a catalytic domain<BR /> | **[[3ecm]] – hPDE 8a catalytic domain<BR /> | ||
**[[3ecn]] – hPDE 8a catalytic domain + inhibitor<br /> | **[[3ecn]], [[7cwf]], [[7cwg]] – hPDE 8a catalytic domain + inhibitor<br /> | ||
**[[7cwa]] - hPDE 8a catalytic domain + leukemia drug<br /> | |||
*PDE 9 | *PDE 9 | ||
**[[2hd1]], [[2yy2]], [[3jsi]], [[3jsw]], [[3k3e]], [[3k3h]], [[4e90]], [[4g2j]], [[4g2l]], [[4gh6]],[[4y8c]], [[4y87]], [[4y86]], [[6a3n]] - hPDE 6d δ subunit + RPGR<br /> | **[[2hd1]], [[2yy2]], [[3jsi]], [[3jsw]], [[3k3e]], [[3k3h]], [[4e90]], [[4g2j]], [[4g2l]], [[4gh6]],[[4y8c]], [[4y87]], [[4y86]], [[6a3n]], [[6lzz]] - hPDE 6d δ subunit + RPGR<br /> | ||
**[[3n3z]], [[3qi3]], [[3qi4]] - hPDE 9a catalytic domain (mutant) + inhibitor<br /> | **[[3n3z]], [[3qi3]], [[3qi4]] - hPDE 9a catalytic domain (mutant) + inhibitor<br /> | ||
**[[3dy8]], [[3dyl]], [[3dyn]], [[3dyq]], [[3dys]] - hPDE 9 catalytic domain + GMP<br /> | **[[3dy8]], [[3dyl]], [[3dyn]], [[3dyq]], [[3dys]] - hPDE 9 catalytic domain + GMP<br /> | ||
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**[[2zmf]] – hPDE 10a C terminal<BR /> | **[[2zmf]] – hPDE 10a C terminal<BR /> | ||
**[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR /> | **[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR /> | ||
**[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]], [[4yqh]], [[4ys7]], [[3ws8]], [[3ws9]], [[3wyk]], [[3wyl]], [[3wym]], [[4mrw]], [[4mrz]], [[4ms0]], [[4msa]], [[4msc]], [[4mse]], [[4msh]], [[4msn]], [[5uwf]], [[5k9r]], [[5i2r]], [[5edi]], [[5edh]], [[5edg]], [[5ede]], [[5dh5]], [[5dh4]], [[5c2h]], [[5c2e]], [[5c2a]], [[5c29]], [[5c28]], [[5c1w]], [[5b4k]], [[5b4l]], [[5axq]], [[5axp]], [[4zo5]], [[4xy2]], [[4wn1]], [[4tpp]], [[4tpm]], [[4phw]], [[4p1r]], [[4p0n]], [[5xuj]], [[5xui]], [[6msc]], [[6msa]], [[6ke0]], [[6kdz]], [[6kdx]], [[6iji]], [[6ijh]], [[5znl]], [[6ko0]], [[6ko1]] - hPDE 10a catalytic domain + inhibitor<br /> | **[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]], [[4yqh]], [[4ys7]], [[3ws8]], [[3ws9]], [[3wyk]], [[3wyl]], [[3wym]], [[4mrw]], [[4mrz]], [[4ms0]], [[4msa]], [[4msc]], [[4mse]], [[4msh]], [[4msn]], [[5uwf]], [[5k9r]], [[5i2r]], [[5edi]], [[5edh]], [[5edg]], [[5ede]], [[5dh5]], [[5dh4]], [[5c2h]], [[5c2e]], [[5c2a]], [[5c29]], [[5c28]], [[5c1w]], [[5b4k]], [[5b4l]], [[5axq]], [[5axp]], [[4zo5]], [[4xy2]], [[4wn1]], [[4tpp]], [[4tpm]], [[4phw]], [[4p1r]], [[4p0n]], [[5xuj]], [[5xui]], [[6msc]], [[6msa]], [[6ke0]], [[6kdz]], [[6kdx]], [[6iji]], [[6ijh]], [[5znl]], [[6ko0]], [[6ko1]], [[6kze]], [[7bpi]] - hPDE 10a catalytic domain + inhibitor<br /> | ||
**[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br /> | **[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br /> | ||
**[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR /> | **[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR /> | ||
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**[[4i15]] – TbPDEb1 catalytic domain – ''Trypanosoma brucei''<br /> | **[[4i15]] – TbPDEb1 catalytic domain – ''Trypanosoma brucei''<br /> | ||
**[[5l9h]], [[5l8y]], [[5l8c]], [[5g5v]], [[5g57]], [[5g2b]], [[4phl]], [[6rgk]], [[6rfw]], [[6rfn]], [[6rb6]], [[6gxq]], [[6fv9]], [[6ftm]], [[6frd]], [[6fe3]], [[6fdx]], [[6fdw]], [[6fds]], [[6qgp]], [[6qgu]] – TbPDEb1 catalytic domain + inhibitor<br /> | **[[5l9h]], [[5l8y]], [[5l8c]], [[5g5v]], [[5g57]], [[5g2b]], [[4phl]], [[6rgk]], [[6rfw]], [[6rfn]], [[6rb6]], [[6gxq]], [[6fv9]], [[6ftm]], [[6frd]], [[6fe3]], [[6fdx]], [[6fdw]], [[6fds]], [[6qgp]], [[6qgu]], [[7a28]], [[7a2f]] – TbPDEb1 catalytic domain + inhibitor<br /> | ||
*PDE b2 | *PDE b2 | ||
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**[[1nop]], [[1rff]], [[1rfi]], [[1rg1]], [[1rg2]], [[1rgt]] - hPDE1 catalytic domain (mutant) + DNA + topoisomerase peptide + VO4<BR /> | **[[1nop]], [[1rff]], [[1rfi]], [[1rg1]], [[1rg2]], [[1rgt]] - hPDE1 catalytic domain (mutant) + DNA + topoisomerase peptide + VO4<BR /> | ||
**[[1rgu]], [[1rh0]] - hPDE1 catalytic domain (mutant) + polynucleotide + neurohormone<br /> | **[[1rgu]], [[1rh0]] - hPDE1 catalytic domain (mutant) + polynucleotide + neurohormone<br /> | ||
**[[6n19]], [[6n17]], [[6n0r]], [[6n0o]], [[6n0n]], [[6n0d]], [[6mz0]], [[6myz]], [[6mj5]], [[6djj]], [[6dji]], [[6djh]], [[6djg]], [[6djf]], [[6dje]], [[6djd]], [[6dim]], [[6dih]], [[6die]], [[6dhu]] - hPDE catalytic domain + inhibitor<br /> | **[[6n19]], [[6n17]], [[6n0r]], [[6n0o]], [[6n0n]], [[6n0d]], [[6mz0]], [[6myz]], [[6mj5]], [[6djj]], [[6dji]], [[6djh]], [[6djg]], [[6djf]], [[6dje]], [[6djd]], [[6dim]], [[6dih]], [[6die]], [[6dhu]], [[6w4r]], [[6w7j]], [[6w7k]], [[6w7l]] - hPDE catalytic domain + inhibitor<br /> | ||
**[[5j3s]], [[5j3p]] - hPDE catalytic domain (mutant) + inhibitor<br /> | **[[5j3s]], [[5j3p]] - hPDE catalytic domain (mutant) + inhibitor<br /> | ||
**[[5nwa]], [[5nw9]] – hPDE1 residues 1-148 + DNA <br /> | **[[5nwa]], [[5nw9]] – hPDE1 residues 1-148 + DNA <br /> | ||
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**[[5gz4]] – TacPDE – Taiwan cobra<br /> | **[[5gz4]] – TacPDE – Taiwan cobra<br /> | ||
**[[5gz5]] – TacPDE + AMP <br /> | **[[5gz5]] – TacPDE + AMP <br /> | ||
**[[7cba]] – TacPDE + flavonoid <br /> | |||
**[[2ahd]] – PDE – ''Methanocaldococcus jannaschii''<BR /> | **[[2ahd]] – PDE – ''Methanocaldococcus jannaschii''<BR /> | ||
**[[3qvq]] – PDE + P3G– ''Oleispira antarctica''<br /> | **[[3qvq]] – PDE + P3G– ''Oleispira antarctica''<br /> | ||
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**[[5xsn]] – SaPDE catalytic domain + C-di-AMP<br /> | **[[5xsn]] – SaPDE catalytic domain + C-di-AMP<br /> | ||
**[[5xsp]] – SaPDE catalytic domain + AMP<br /> | **[[5xsp]] – SaPDE catalytic domain + AMP<br /> | ||
**[[5vyd]] – PDE – ''Salpingoeca rosetta''<br /> | **[[5vyd]], [[7d7p]] – SrPDE PDE domain 387-704 – ''Salpingoeca rosetta''<br /> | ||
**[[7cj3]], [[7d7q]] – SrPDE TM domain 33-378<br /> | |||
**[[5o7f]] – TmPDE (mutant) + GMP<br /> | **[[5o7f]] – TmPDE (mutant) + GMP<br /> | ||
**[[5o1u]] – TmPDE + AMP<br /> | **[[5o1u]] – TmPDE + AMP<br /> | ||