1fv2: Difference between revisions

Revision as of 16:47, 2 May 2008

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B

OverviewOverview

Tetanus toxin, a member of the family of Clostridial neurotoxins, is one of the most potent toxins known. The crystal structure of the complex of the COOH-terminal fragment of the heavy chain with an analogue of its ganglioside receptor, GT1b, provides the first direct identification and characterization of the ganglioside-binding sites. The ganglioside induces cross-linking by binding to two distinct sites on the Hc molecule. The structure sheds new light on the binding of Clostridial neurotoxins to receptors on neuronal cells and provides important information relevant to the design of anti-tetanus and anti-botulism therapeutic agents.

About this StructureAbout this Structure

1FV2 is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin., Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW, J Biol Chem. 2001 Aug 24;276(34):32274-81. Epub 2001 Jun 19. PMID:11418600 Page seeded by OCA on Fri May 2 16:47:47 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1fv2.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1fv2 |SIZE=350|CAPTION= <scene name='initialview01'>1fv2</scene>, resolution 2.5&Aring;
+The line below this paragraph, containing "STRUCTURE_1fv2", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1fv2|  PDB=1fv2  |  SCENE=  }}
-|RELATEDENTRY=[[1d0h|1d0h]], [[1dll|1dll]], [[1diw|1diw]], [[1dfq|1dfq]], [[1af9|1af9]], [[1a8d|1a8d]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv2 OCA], [http://www.ebi.ac.uk/pdbsum/1fv2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fv2 RCSB]</span>
-}}
 '''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B'''
@@ Line 35: / Line 32: @@
 [[Category: Kiso, M.]]
 [[Category: Sinha, K A.]]
-[[Category: carbohydrate]]
+[[Category: Carbohydrate]]
-[[Category: ganglioside]]
+[[Category: Ganglioside]]
-[[Category: multi-valent binding]]
+[[Category: Multi-valent binding]]
-[[Category: receptor]]
+[[Category: Receptor]]
-[[Category: toxin]]
+[[Category: Toxin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:47:47 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:30:50 2008''