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==CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 SYN COMPLEX (1 WK)== | ==CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 SYN COMPLEX (1 WK)== | ||
<StructureSection load='2xui' size='340' side='right' caption='[[2xui]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2xui' size='340' side='right'caption='[[2xui]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xui]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2xui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ5:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-PHENANTHRIDINIUM'>TZ5</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ5:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-PHENANTHRIDINIUM'>TZ5</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jgh|2jgh]], [[2whq|2whq]], [[1mah|1mah]], [[2ha6|2ha6]], [[1maa|1maa]], [[2c0q|2c0q]], [[2jgg|2jgg]], [[2jgl|2jgl]], [[2xug|2xug]], [[1q84|1q84]], [[2xud|2xud]], [[2jgm|2jgm]], [[2jge|2jge]], [[1q83|1q83]], [[2wls|2wls]], [[2xup|2xup]], [[1c2b|1c2b]], [[2ha3|2ha3]], [[2ha0|2ha0]], [[2wu3|2wu3]], [[2xuf|2xuf]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2jgj|2jgj]], [[1j06|1j06]], [[2c0p|2c0p]], [[2jf0|2jf0]], [[2xuo|2xuo]], [[2h9y|2h9y]], [[2whr|2whr]], [[1n5m|1n5m]], [[2ha5|2ha5]], [[2ha2|2ha2]], [[2xuq|2xuq]], [[2whp|2whp]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2jgf|2jgf]], [[2ha7|2ha7]], [[2wu4|2wu4]], [[1c2o|1c2o]], [[2xuk|2xuk]], [[2xuj|2xuj]], [[2xuh|2xuh]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jgh|2jgh]], [[2whq|2whq]], [[1mah|1mah]], [[2ha6|2ha6]], [[1maa|1maa]], [[2c0q|2c0q]], [[2jgg|2jgg]], [[2jgl|2jgl]], [[2xug|2xug]], [[1q84|1q84]], [[2xud|2xud]], [[2jgm|2jgm]], [[2jge|2jge]], [[1q83|1q83]], [[2wls|2wls]], [[2xup|2xup]], [[1c2b|1c2b]], [[2ha3|2ha3]], [[2ha0|2ha0]], [[2wu3|2wu3]], [[2xuf|2xuf]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2jgj|2jgj]], [[1j06|1j06]], [[2c0p|2c0p]], [[2jf0|2jf0]], [[2xuo|2xuo]], [[2h9y|2h9y]], [[2whr|2whr]], [[1n5m|1n5m]], [[2ha5|2ha5]], [[2ha2|2ha2]], [[2xuq|2xuq]], [[2whp|2whp]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2jgf|2jgf]], [[2ha7|2ha7]], [[2wu4|2wu4]], [[1c2o|1c2o]], [[2xuk|2xuk]], [[2xuj|2xuj]], [[2xuh|2xuh]]</div></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xui OCA], [https://pdbe.org/2xui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xui RCSB], [https://www.ebi.ac.uk/pdbsum/2xui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xui ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Acetylcholinesterase | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Large Structures]] | |||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Bourne, Y]] | [[Category: Bourne, Y]] |