2xsn: Difference between revisions

<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XSN FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_3-monooxygenase Tyrosine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.2 1.14.16.2] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [http://pdbe.org/2xsn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [http://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN]] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry.  May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref>   

[[http://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN]] Plays an important role in the physiology of adrenergic neurons.