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==Crystal structure of human Cathepsin-S with bound ligand==
==Crystal structure of human Cathepsin-S with bound ligand==
<StructureSection load='5qcc' size='340' side='right' caption='[[5qcc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5qcc' size='340' side='right'caption='[[5qcc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5qcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCC FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QCC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGY:tert-butyl+4-(2-{3-(4-chloro-3-iodophenyl)-1-[3-(morpholin-4-yl)propyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}-2-oxoethyl)piperidine-1-carboxylate'>BGY</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcc OCA], [https://pdbe.org/5qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qcc RCSB], [https://www.ebi.ac.uk/pdbsum/5qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcc ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcc OCA], [http://pdbe.org/5qcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qcc RCSB], [http://www.ebi.ac.uk/pdbsum/5qcc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.


==See Also==
==See Also==
*[[Cathepsin|Cathepsin]]
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cathepsin S]]
[[Category: Large Structures]]
[[Category: Human]]
[[Category: Ameriks MK]]
[[Category: Ameriks, M K]]
[[Category: Bembenek SD]]
[[Category: Bembenek, S D]]
[[Category: Burley SK]]
[[Category: Burley, S K]]
[[Category: Mirzadegan T]]
[[Category: Mirzadegan, T]]
[[Category: Shao C]]
[[Category: Shao, C]]
[[Category: Yang H]]
[[Category: Yang, H]]
[[Category: Cathepsin s]]
[[Category: D3r]]
[[Category: Hydrolase]]
[[Category: Ligand docking]]

Revision as of 17:06, 17 November 2021

Crystal structure of human Cathepsin-S with bound ligandCrystal structure of human Cathepsin-S with bound ligand

Structural highlights

Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

Drag the structure with the mouse to rotate

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OCA
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