Thioether protein crosslinks: Difference between revisions
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Thioether bonds between cysteine and ligands are common, but are generally not crosslinks between polypeptides. Thioether bonds between '''cysteine and the vinyl groups of hemes''' are common. Diverse other '''ligands''' are bonded to protein via cysteine thioether linkages. | Thioether bonds between cysteine and ligands are common, but are generally not crosslinks between polypeptides. Thioether bonds between '''cysteine and the vinyl groups of hemes''' are common. Diverse other '''ligands''' are bonded to protein via cysteine thioether linkages. | ||
Note that the sidechain of methionine contains a thioether. | Note that the '''sidechain of methionine''' contains a thioether (which is not a protein crosslink). | ||
An accurate estimate of the frequency of thioether crosslinks in the [[PDB]] may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character [[PDB codes]]. | An accurate estimate of the frequency of thioether crosslinks in the [[PDB]] may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character [[PDB codes]]. | ||