2kzu: Difference between revisions

<table><tr><td colspan='2'>[[2kzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZU FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kzs|2kzs]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DAXX, DADB-159G18.9-007, DAMC-227D19.15-007, DAQB-126H3.2-007, XXbac-BCX165D10.3-007, XXbac-BPG185D15.6-007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RASSF1, hCG_17462 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzu OCA], [http://pdbe.org/2kzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kzu RCSB], [http://www.ebi.ac.uk/pdbsum/2kzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzu ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RASF1_HUMAN RASF1_HUMAN]] Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.<ref>PMID:10888881</ref> <ref>PMID:11333291</ref> <ref>PMID:12024041</ref> <ref>PMID:14743218</ref> <ref>PMID:15109305</ref> <ref>PMID:15949439</ref> <ref>PMID:16510573</ref> <ref>PMID:18566590</ref> <ref>PMID:21199877</ref>