2jp2: Difference between revisions

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<StructureSection load='2jp2' size='340' side='right'caption='[[2jp2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2jp2' size='340' side='right'caption='[[2jp2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jp2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JP2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jp2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JP2 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPRED2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPRED2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp2 OCA], [http://pdbe.org/2jp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jp2 RCSB], [http://www.ebi.ac.uk/pdbsum/2jp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jp2 OCA], [https://pdbe.org/2jp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jp2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPRE2_HUMAN SPRE2_HUMAN]] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.  
[[https://www.uniprot.org/uniprot/SPRE2_HUMAN SPRE2_HUMAN]] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 11:30, 10 November 2021

Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)

Structural highlights

2jp2 is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:SPRED2 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SPRE2_HUMAN] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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OCA