Mineralocorticoids: Difference between revisions

Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky

@@ Line 1: / Line 1: @@
-<StructureSection load='' size='350' side='right' caption='Glycosylated human mineralocorticoid receptor ligand-binding domain complex with aldosterone, glycerol and sulfate (PDB entry [[2aa2]])' scene='78/781019/Cv/1'>
+<StructureSection load='' size='300' side='right' caption='Glycosylated human mineralocorticoid receptor ligand-binding domain complex with aldosterone, glycerol and sulfate (PDB entry [[2aa2]])' scene='78/781019/Cv/1'>
-This is a default text for your page '''Mineralocorticoids'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
+*[[Mineralocorticoid receptor]] (MR) in epithelial cells is activated by the mineralocorticoid hormone aldosterone promoting renal sodium retention and potassium excretion. It is [[Nuclear receptors|nuclear receptor]]. In non epithelial cells MR is activated by cortisol<ref>PMID:15199296</ref>.  MR is exposed to many steroids including cortisol, cortisone and progesterone, however, aldosterone and deoxycorticosterone are its physiological ligands. MR mutations are the principal cause of renal pseudohypoaldosteronism<ref>PMID:16972228</ref>. MR mutation S810L causes early-onset hypertension<ref>PMID:10884226</ref>. Inhibition of cardia MR prevents doxorubicin-induced cardiotoxicity<ref>PMID:28430882</ref>. MR is an important proadipogenic transcription factor that may mediate aldosterone and glucocorticoid effects on adipose tissue development and hence on obesity and development of metabolic syndrome<ref>PMID:17384139</ref>. The MR ligand aldosterone binds in a <scene name='78/781019/Cv/6'>fully enclosed pocket, contacting residues with six α-helices and a β-turn</scene> ({{Template:ColorKey_Helix}},{{Template:ColorKey_Strand}},{{Template:ColorKey_Loop}},{{Template:ColorKey_Turn}}). <scene name='78/781019/Cv/7'>It forms hydrogen bonds with 4 MR residues</scene><ref>PMID:15967794</ref>. <scene name='78/781019/Cv/8'>Whole binding site</scene>. Water molecules are shown as red spheres.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
-== Function ==
+*[[Angiotensin-Converting Enzyme]], Renin-Angiotensin-Aldosterone System.
-== Disease ==
-== Relevance ==
-== Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
 </StructureSection>
 == References ==
 <references/>