1bb5: Difference between revisions

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 ==HUMAN LYSOZYME MUTANT A96L COMPLEXED WITH CHITOTRIOSE==
-<StructureSection load='1bb5' size='340' side='right'caption='[[1bb5]]' scene=''>
+<StructureSection load='1bb5' size='340' side='right'caption='[[1bb5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BB5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BB5 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bb5 OCA], [https://pdbe.org/1bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bb5 ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bb5 OCA], [https://pdbe.org/1bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bb5 ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[https://omim.org/entry/105200 105200]]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref>
+== Function ==
+[[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 19: / Line 25: @@
 ==See Also==
 *[[Lysozyme 3D structures|Lysozyme 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Human]]
 [[Category: Large Structures]]
-[[Category: Headley AG]]
+[[Category: Lysozyme]]
-[[Category: Pearl LH]]
+[[Category: Headley, A G]]
-[[Category: Roe SM]]
+[[Category: Pearl, L H]]
+[[Category: Roe, S M]]
+[[Category: Glycosidase]]
+[[Category: Hydrolase]]