1flj: Difference between revisions

Revision as of 16:28, 2 May 2008

CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III

OverviewOverview

S-Glutathiolation of carbonic anhydrase III (CAIII) occurs rapidly in hepatocytes under oxidative stress. The crystal structure of the S-glutathiolated CAIII from rat liver reveals covalent adducts on cysteines 183 and 188. Electrostatic charge and steric contacts at each modification site inversely correlate with the relative rates of reactivity of these cysteines toward glutathione (GSH). Diffuse electron density associated with the GSH adducts suggests a lack of preferred bonding interactions between CAIII and the glutathionyl moieties. Hence, the GSH adducts are available for binding by a protein capable of reducing this mixed disulfide. These properties are consistent with the participation of CAIII in the protection/recovery from the damaging effects of oxidative agents.

About this StructureAbout this Structure

1FLJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of S-glutathiolated carbonic anhydrase III., Mallis RJ, Poland BW, Chatterjee TK, Fisher RA, Darmawan S, Honzatko RB, Thomas JA, FEBS Lett. 2000 Oct 6;482(3):237-41. PMID:11024467 Page seeded by OCA on Fri May 2 16:28:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1flj.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1flj |SIZE=350|CAPTION= <scene name='initialview01'>1flj</scene>, resolution 1.80&Aring;
+The line below this paragraph, containing "STRUCTURE_1flj", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GTT:GLUTATHIONE'>GTT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1flj|  PDB=1flj  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1flj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1flj OCA], [http://www.ebi.ac.uk/pdbsum/1flj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1flj RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III'''
@@ Line 33: / Line 30: @@
 [[Category: Poland, B W.]]
 [[Category: Thomas, J A.]]
-[[Category: carbonic anhydrase iii]]
+[[Category: Carbonic anhydrase iii]]
-[[Category: glutathione]]
+[[Category: Glutathione]]
-[[Category: s-glutathiolated]]
+[[Category: S-glutathiolated]]
-[[Category: s-glutathionylated]]
+[[Category: S-glutathionylated]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:28:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:25:20 2008''