Lysine-cysteine NOS bonds: Difference between revisions
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A survey of the data in the [[Protein Data Bank]] revealed that the NOS bond likely exists "in diverse protein families across all domains of life (including ''Homo sapiens'') and that it is often located at catalytic or regulatory hotspots."<ref name="wensien2021" /> Because the NOS bond was unknown before 2021, it could easily have been overlooked in earlier interpretations of [[electron density maps]].<ref name="wensien2021" /> Three examples are given illustrating putative NOS bonds in active sites of enzymes which, if correct, were previously overlooked: | A survey of the data in the [[Protein Data Bank]] revealed that the NOS bond likely exists "in diverse protein families across all domains of life (including ''Homo sapiens'') and that it is often located at catalytic or regulatory hotspots."<ref name="wensien2021" /> Because the NOS bond was unknown before 2021, it could easily have been overlooked in earlier interpretations of [[electron density maps]].<ref name="wensien2021" /> Three examples are given illustrating putative NOS bonds in active sites of enzymes which, if correct, were previously overlooked: | ||
*[[1m3q]], a DNA glycosylase: Lys249 – Cys253. | *[[1m3q]] 2004, a DNA glycosylase: Lys249 – Cys253. | ||
*[[5y72]], a prenyltransferase: Lys275 – Cys223. | *[[5y72]] 2018, a prenyltransferase: Lys275 – Cys223. | ||
*[[6t3x]], a cytomegalovirus nuclear egress protein: Lys132 – Cys54. | *[[6t3x]] 2020, a cytomegalovirus nuclear egress protein: Lys132 – Cys54. | ||
==Methods== | ==Methods== | ||