2b9r: Difference between revisions
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<StructureSection load='2b9r' size='340' side='right'caption='[[2b9r]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='2b9r' size='340' side='right'caption='[[2b9r]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2b9r]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2b9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9R FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9r OCA], [https://pdbe.org/2b9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9r RCSB], [https://www.ebi.ac.uk/pdbsum/2b9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/CCNB1_HUMAN CCNB1_HUMAN]] Essential for the control of the cell cycle at the G2/M (mitosis) transition.<ref>PMID:17495531</ref> <ref>PMID:17495533</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 20:16, 20 October 2021
Crystal Structure of Human Cyclin B1Crystal Structure of Human Cyclin B1
Structural highlights
Function[CCNB1_HUMAN] Essential for the control of the cell cycle at the G2/M (mitosis) transition.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedCyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. Cyclin B regulates the activation, subcellular localization, and substrate specificity of cdk1, and destruction of cyclin B is necessary for mitotic exit. Overexpression of human cyclin B1 has been found in numerous cancers and has been associated with tumor aggressiveness. Here we report the crystal structure of human cyclin B1 to 2.9 A. Comparison of the structure with cyclin A and cyclin E reveals remarkably similar N-terminal cyclin box motifs but significant differences among the C-terminal cyclin box lobes. Divergence in sequence gives rise to unique interaction surfaces at the proposed cyclin B/cdk1 interface as well as the 'RxL' motif substrate binding site on cyclin B. Examination of the structure provides insight into the molecular basis for differential affinities of protein based cyclin/cdk inhibitors such as p27, substrate recognition, and cdk interaction. The crystal structure of human cyclin B.,Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R Cell Cycle. 2007 Jun 1;6(11):1342-9. Epub 2007 Jun 14. PMID:17495533[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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