1uue: Difference between revisions
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<StructureSection load='1uue' size='340' side='right'caption='[[1uue]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='1uue' size='340' side='right'caption='[[1uue]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1uue]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1uue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UUE FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aey|1aey]], [[1aj3|1aj3]], [[1bk2|1bk2]], [[1cun|1cun]], [[1e6g|1e6g]], [[1e6h|1e6h]], [[1e7o|1e7o]], [[1g2b|1g2b]], [[1h8k|1h8k]], [[1hd3|1hd3]], [[1m8m|1m8m]], [[1neg|1neg]], [[1pwt|1pwt]], [[1qkw|1qkw]], [[1qkx|1qkx]], [[1shg|1shg]], [[1tuc|1tuc]], [[1tud|1tud]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aey|1aey]], [[1aj3|1aj3]], [[1bk2|1bk2]], [[1cun|1cun]], [[1e6g|1e6g]], [[1e6h|1e6h]], [[1e7o|1e7o]], [[1g2b|1g2b]], [[1h8k|1h8k]], [[1hd3|1hd3]], [[1m8m|1m8m]], [[1neg|1neg]], [[1pwt|1pwt]], [[1qkw|1qkw]], [[1qkx|1qkx]], [[1shg|1shg]], [[1tuc|1tuc]], [[1tud|1tud]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uue OCA], [https://pdbe.org/1uue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uue RCSB], [https://www.ebi.ac.uk/pdbsum/1uue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uue ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
Revision as of 12:42, 29 September 2021
a-SPECTRIN SH3 DOMAIN (V44T, D48G MUTANT)a-SPECTRIN SH3 DOMAIN (V44T, D48G MUTANT)
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedAn effort to combine theoretical analyses and protein engineering methods has been made to probe the folding mechanism of SH3 by using Energy Landscape Theory and a phi-value analysis. Particular emphasis was given to core residues and the effect of desolvation during the folding event by replacing the core valines with isosteric threonines. These mutations have the advantage of keeping the core structurally invariant while affecting core stability relative to the unfolded state. Although the valines that form the core appear spatially invariant, the folding kinetics of their threonine mutants varies, indicating their different extent of solvation in the transition-state ensemble. Theoretical studies predicted the distribution of folding kinetics of threonine mutants without previous knowledge of the measured rates. This initial success encourages further investigations of the molecular details behind these macroscopic phenomena and of the role of solvation in the folding mechanism. Solvation in protein folding analysis: combination of theoretical and experimental approaches.,Fernandez-Escamilla AM, Cheung MS, Vega MC, Wilmanns M, Onuchic JN, Serrano L Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2834-9. Epub 2004 Feb 20. PMID:14978284[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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