1faw: Difference between revisions

Revision as of 16:07, 2 May 2008

GRAYLAG GOOSE HEMOGLOBIN (OXY FORM)

OverviewOverview

The greylag goose (Anser anser), which lives on lowlands and cannot tolerate hypoxic conditions, presents a striking contrast to its close relative the bar-headed goose (A. indicus), which lives at high altitude and possesses high-altitude hypoxia adaptation. There are only four amino-acid residue differences at alpha18, alpha63, alpha119 and beta125 between the haemoglobins of the two species. The crystal structure of greylag goose oxy haemoglobin was determined at 3.09 A resolution. Its quaternary structure is slightly different from that of the bar-headed goose oxy haemoglobin, with a rotation of 2.8 degrees in relative orientation of the two dimers. Of the four mutations, those at alpha119 and beta125 produce contact changes in the alpha(1)beta(1) interface and may be responsible for the differences in intrinsic oxygen affinity between the two species; those at alpha18 and alpha63 may be responsible for the differences in quaternary structure between the two species.

About this StructureAbout this Structure

1FAW is a Protein complex structure of sequences from Anser anser. Full crystallographic information is available from OCA.

ReferenceReference

The structure of greylag goose oxy haemoglobin: the roles of four mutations compared with bar-headed goose haemoglobin., Liang YH, Liu XZ, Liu SH, Lu GY, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1850-6. Epub 2001, Nov 21. PMID:11717498 Page seeded by OCA on Fri May 2 16:06:59 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1faw.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1faw |SIZE=350|CAPTION= <scene name='initialview01'>1faw</scene>, resolution 3.09&Aring;
+The line below this paragraph, containing "STRUCTURE_1faw", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1faw|  PDB=1faw  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1faw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1faw OCA], [http://www.ebi.ac.uk/pdbsum/1faw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1faw RCSB]</span>
-}}
 '''GRAYLAG GOOSE HEMOGLOBIN (OXY FORM)'''
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 [[Category: Liu, X Z.]]
 [[Category: Lu, G Y.]]
-[[Category: erythrocyte]]
+[[Category: Erythrocyte]]
-[[Category: heme]]
+[[Category: Heme]]
-[[Category: oxygen transport]]
+[[Category: Oxygen transport]]
-[[Category: respiratory protein]]
+[[Category: Respiratory protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:06:59 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:23 2008''