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{{STRUCTURE_1f81| PDB=1f81 | SCENE= }} | |||
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'''SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP''' | '''SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP''' | ||
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[[Category: Martinez-Yamout, M.]] | [[Category: Martinez-Yamout, M.]] | ||
[[Category: Wright, P E.]] | [[Category: Wright, P E.]] | ||
[[Category: | [[Category: Cbp]] | ||
[[Category: | [[Category: Taz2]] | ||
[[Category: | [[Category: Zinc finger]] | ||
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Revision as of 16:00, 2 May 2008
SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP
OverviewOverview
The TAZ2 (CH3) domain of the transcriptional adapter protein CBP has been implicated in direct functional interactions with numerous cellular transcription factors and viral oncoproteins. The solution structure of the TAZ2 domain of murine CBP has been determined by nuclear magnetic resonance (NMR). The protein adopts a novel helical fold stabilized by three zinc ions, each of which is bound to one histidine and three cysteine ligands in HCCC-type motifs. Each zinc-binding site is formed from the carboxy terminus of an alpha-helix, a short loop, and the amino terminus of the next alpha-helix. A peptide derived from the N-terminal transactivation domain of p53 binds specifically to one face of the TAZ2 domain. The close similarities between the TAZ2 and TAZ1 (CH1 domain of CBP/p300) sequences suggest that both domains will adopt similar three-dimensional structures.
About this StructureAbout this Structure
1F81 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP., De Guzman RN, Liu HY, Martinez-Yamout M, Dyson HJ, Wright PE, J Mol Biol. 2000 Oct 20;303(2):243-53. PMID:11023789 Page seeded by OCA on Fri May 2 16:00:41 2008