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==Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside== | ==Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside== | ||
<StructureSection load='7ots' size='340' side='right'caption='[[7ots]]' scene=''> | <StructureSection load='7ots' size='340' side='right'caption='[[7ots]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTS FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ots]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTS FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ots FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ots OCA], [https://pdbe.org/7ots PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ots RCSB], [https://www.ebi.ac.uk/pdbsum/7ots PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ots ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABHD6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acylglycerol_lipase Acylglycerol lipase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.23 3.1.1.23] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ots FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ots OCA], [https://pdbe.org/7ots PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ots RCSB], [https://www.ebi.ac.uk/pdbsum/7ots PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ots ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/ABHD6_HUMAN ABHD6_HUMAN]] Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).[UniProtKB:Q8R2Y0]<ref>PMID:22969151</ref> <ref>PMID:26491015</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Acylglycerol lipase]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Miallau L]] | [[Category: Miallau, L]] | ||
[[Category: Nawrotek A]] | [[Category: Nawrotek, A]] | ||
[[Category: Talagas A]] | [[Category: Talagas, A]] | ||
[[Category: Vuillard L]] | [[Category: Vuillard, L]] | ||
[[Category: 2-ag signalling]] | |||
[[Category: 2-arachidonoylglycerol hydrolase]] | |||
[[Category: Alpha/beta-hydrolase domain containing 6]] | |||
[[Category: Endocannabinoid system]] | |||
[[Category: Hydrolase]] | |||
[[Category: Monoacylglycerol lipase abhd6]] | |||
[[Category: Nervous system]] | |||
Revision as of 09:38, 25 August 2021
Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucosideCrystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside
Structural highlights
Function[ABHD6_HUMAN] Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).[UniProtKB:Q8R2Y0][1] [2] References
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